Drug Localization in Tissues and Cells - Receptor Micro Autoradiography
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Leica CM3050S
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Cellular and subcellular detail can be viewed. Associated radioactivity can be characterized and quantified. Time- and dose-related data of different compounds can be compared. A receptor-drug-homunculus can be created as a computer model to provide overviews and details about sites of deposition and specific binding, receptor-drug half lives, hierarchies of target affinities, and indications for therapeutic indices, side effects and toxicity.

Documentation of precise localization can give important clues for drug functions and can serve as a guide for histochemical, biochemical, functional and clinical follow-up for the development of new therapeutic applications. With its high diagnostic and predictive qualities, receptor micro-autoradiography is an indispensable tool for drug research and development.