Deficiencies of the HLA class-I antigen processing pathway: Tumor-escape of renal cell carcinomas

Download Area

In recent years the identification and characterization of the different components of the HLA class I antigen-processing and -presentation machinery gained further insight into the underlying molecular mechanisms of immune surveillance. The results of the study presented here indicate that downregulation and/or loss of HLA class I molecules is a relative frequent event and may constitute a mechanism by which renal carcinoma cells evade immune recognition.

D. Atkins (1), B. Seliger (2), S. Störkel (1)
(1)Institut für Pathologie der Universität Witten/Herdecke, Klinikum Barmen,Wuppertal, Germany
(2) III. Med. Klinik und Poliklinik,Klinikum der Johannes Gutenberg-Universität, Mainz, Germany
Scientific and Technical Information
Edition CDR 3, pp. 20–40
November 1999