Why are frozen sections generally so inferior to paraffin sections? FAQ Report When a cut section is mounted on a room temperature slide, the melting ice causes water-soluble components of the cell to be displaced by the flow. Slow freezing produces large ice-crystals which damage insoluble structural elements and cause displacements of water-soluble components. When unfixed wet or dry sections are placedin aqueous solutions (even aqueous fixatives) water soluble substances wash out of the sections.