What would cause a frozen section to be inferior to a paraffin section? FAQ Report Slow, poor freezing produces large hexagonal ice-crystals within the tissue that can damage insoluble structural elements and cause displacement of water-soluble components. Melting ice from mounting the frozen section on a room temperature slide causes water-soluble components of the cell to be displaced by the flow. Water-soluble substances may wash out of the sections when unfixed wet or dry sections are placed in aqueous solutions (even aqueous fixatives).