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Micromanipulation

In many time-lapse or multi-dimensional experiments, cell manipulation is the starting point for subsequent analysis. Microinjection with DNA, RNA or probes into adherent cells enable you to better understand pathways and intracellular machinery. DNA, stem cells or spermatozoa microinjection into oocytes or blastocysts are performed to create transgenic or cloned organisms, or to fertilize oocytes for Assisted Reproductive Technology (ART), such as in vitro fertilization (IVF).

Furthermore the CRISPR/Cas9 technique is used to produce transgene animals. With several Leica configurations to meet your needs and budget, you will be sure to find the perfect micromanipulation solution.

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Want to know more on our solutions for Micromanipulation?


Perfect Stability

Creating a vibration-free setup and obtaining outstanding optics to visualize tiny particles for microinjection (e.g. pronuclei) are the major challenges for micromanipulation.

Offering superior precision, Mechanical Manipulators by Leica Microsystems are ideal for life science applications where micro surgical, physiological, or chemical operations are performed on live organisms such as oocytes, adherent cells, and plant cells. Typical applications include microinjection in adherent cells, transgenics, and work involving stem cells.

Leica DMi8 offers a stable platform for micromanipulation

The Leica DMi8 offers a stable, ergonomic, and flexible microscope platform along with a variety of contrasting methods for visualizing cells. In combination with the micromanipulator of choice, you can create a perfectly matched system to work with your cells.

Brilliant Image Quality

Visualize small structures, such as sperm heads, with the highest resolution and contrast. With superb contrast methods, such as Integrated Modulation Contrast and DIC, and a variety of high quality objectives to choose from, you will see tiny structures with clarity.

Keep the Specimen in View

Zoom in and out without switching objectives and losing sight of moving specimens. The Leica variozoom camera c-mount allows you to increase and decrease the magnification with just a turn of the adaptor - perfect to keep fast moving specimen like spermatocytes in view while changing magnification to check morphology or catch a sperm for injection.

Concentrate on Your Work

Change contrast methods or magnification with just one press of the button on the touch screen or microscope.

Intelligent automation in the Leica DMi8 selects the right optical elements to visualize your specimen at its best.

Convenient and Ergonomic Remote Control

Easily control the focus and stage movements via the Leica Smart Move placed next to your microscope.


Leica MATS

MATS = Microscope-stage Automatic Thermocontrol System

Maintain the Right Temperature

  • The Leica MATS heated stage insert works in combination with dry and oil objectives up to 100x.
  • With precise and stable temperature control, you can ensure that sensitive samples are kept at the right temperature.

Configuration example for ICSI

Leica Microsystems and Narishige: a widely used combination around the world. With both manual and motorized oil hydraulic Narishige micromanipulators available, find the option that works best for your needs.

  • DMi8 with manual focus and nosepiece
  • 10x, 20x, 40x objectives
  • Integrated Modulation Contrast
  • Manual three-plate stage
  • Leica MATS 37°C heating insert
  • DFC290 HD camera

Configuration example for pronucleus injection

DMi8 equipped with our mechanical micromanipulators is the workhorse for precision and robustness. The joystick movement transfers directly to the tip of the capillary, without any backlash.

  • DMi8 with motorized focus and nosepiece
  • Touch screen ▪10x, 20x, 40x objectives
  • Differential Interference Contrast (DIC)
  • Manual or motorized three-plate stage
  • DFC290 HD camera

Configuration example for embryonic stem cell transfer

Fully Motorized Micromanipulation: The fully motorized Leica DMi8 and Eppendorf micromanipulators allow you to store and recall important functions, thereby increasing speed and precision. A touch screen can be added for easy and intuitive control of all microscope functions.

  • DMi8 with motorized focus and nosepiece
  • Touch Screen
  • 10x, 20x, 40x objectives
  • Integrated Modulation Contrast and Phase Contrast
  • Manual or motorized three-plate stage
  • DFC290 HD camera

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