Code Red – an Exciting Advance in High-Contrast Clinical IHC/ISH

Leica Microsystems has announced the worldwide release of the new Bond Polymer Refine Red Detection™ system.

This new system uses a Fast Red chromogen for high-contrast clinical staining and is optimized for use on the fully automated Bond™ advanced stainer.

According to Arnd Kaldowski, President of Leica Biosystems, Bond Polymer Refine Red Detection ‘will significantly improve diagnostic confidence and will enable an improved clinical workflow. The Bond Polymer Refine Red Detection is especially useful for prostate biopsies, dermatological staining and for melanomas where the presence of melanin can mask DAB staining. The Detection Kit is IVD labeled for clinical use and the bright fuchsia stain of the Fast Red chromogen provides an excellent contrast to DAB, endogenous melanin and hematoxylin counterstains.

Using the same proven Compact Polymer™ technology as Leica Microsystems’ existing Bond DAB system (Bond Polymer Refine Detection™) means the new Fast Red chromogen will produce staining of the same high quality as the proven DAB system.

Fiona Jackson, Bond reagents Product Manager, describes the technical benefits of Compact Polymer technology: ‘Specificity is excellent due to the polymer’s compact size and ability to localize at the antigen, the increased number of alkaline phosphatase molecules on each polymer enhances sensitivity and the system is completely biotin-free’.