Figure 1: Adaptive dynamic range of the SP detector. The SP detection design using individual point detectors avoids two inherent drawbacks of multianode arrays: Loss of dynamics and spectral gaps. All elements of a multianode array are typically controlled with the same gain. Thus the gain setting must make a compromise between underexposure and saturation in case different channels have non-equal molecular brightness. Spectral gaps between array elements can lead to up to 20 % light loss or else channel cross-talk may become severe. Individual point detectors adapt dynamically to the changing needs of a diverse range of samples.