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Leica EM Cryo CLEM Cryo CLEM

Correlating Cryofixed Biological Samples in the Light- and Electron Microscope Leica EM Cryo CLEM

The innovative Leica EM Cryo CLEM set for widefield lightmicroscopy with the Leica DM6 FS represents the state-of-the art solution for analysis of cryo samples in the cryo light and electron microscope. For easy, contamination-free sample transfer from cryo sample preparation instruments, the cryo transfer shuttle is docked to the Leica EM Cryo stage mounted to the microscope. The Leica EM Cryo CLEM objective with low working distance (< 0,28 mm) for high resolution ensures fast and specific localization of target structures in the light microscopy leading to fast and accurately determine regions of interest in the electron microscope.

For research use only
Leica EM Cryo CLEM set mounted on Leica DM6 FS

Your Advantages

Trust in reliability Find what you are looking for

Trust in reliability

Safely transfer your cryo samples and load them into the cryo stage - the cryo transfer shuttle keeps your samples frost free to yield high quality light microscopy images.

Find what you are looking for

We developed the world`s first cryo objective, so that you can easily and quickly localize target structures. The low working distance for high resolution creates beautiful high image quality - see for yourself!

Save time Automated Coordinate Transfer

Save time

You will find loading and unloading of samples very quick with the sample transfer and loading system. Additionally, you need less time for cryo EM operation and analysis, as samples are in excellent condition and target structures accurately located.



Automated Coordinate Transfer

The LAS X Cryo CLEM software automatically scans the sample and generates a high resolution overview image.

The CLEM Viewer allows fast and precise location of points of interest. CLEM coordinates can subsequently be transferred directly to the electron microscope acquisition software SerialEM for correlation.



See the latest publication:

New hardware and workflowss for semi-automated correlative cryo-fluorescence and cryo-electron microscopy/tomography

Click HERE to see the Article