Digital cameras play a vital role in modern microscope systems. Nowadays digital cameras have even begun to replace oculars in some digital microscopes. Microscope cameras serve users across a broad range of application fields and capture the data that form the basis of further analyses. The microscope optics determine the formation of the image which is then projected onto the camera sensor. So the optics are responsible for the quality of the image that reaches the sensor, while the camera is responsible for the accurate digitization and documentation. The camera must be carefully matched to the microscope and application to ensure the image is accurately captured by the sensor, be it for brightfield or fluorescence imaging.