http://www.leica-microsystems.com/science-lab/topics/stereomicroscopy/topic/topic/19/listPagesForTopic/ Article tagged with Stereo Microscopy en-US Especially in fluorescence microscopy, excitation light is friend and foe in one. On the one hand, energy-rich excitation via a specific light wavelength of the fluorochrome resulting in a bright positive fluorochrome signal is highly welcome. On the other hand, "noise" caused by reflections of excitation light passing through the surfaces of optical elements needs to be extremely slight to generate a perfect black background. This relation is described as "signal-to-noise ratio", which is highly relevant for differentiating optically between fluorescence positive and negative cells. http://www.leica-microsystems.com/science-lab/stereomicroscopes-with-triplebeam-technology/ Tue, 02 Apr 2013 14:35:00 +0200 Björn Fuchs Intravital imaging of inflammatory and remodeling processes has been an important area of research and has also motivated the creation of numerous transgenic reporter mouse models that express fluorescent proteins. Our paper (Kilarski, Güç et al. 2013) describes a new in vivo imaging technique, which design was based on innovative concept of using immunostaining for live cells and tissue structures on surgically exposed mouse dermis without causing harmful immunotoxic effect. http://www.leica-microsystems.com/science-lab/intravital-immunofluorescence-for-visualizing-the-microcirculatory-and-immune-microenvironments-in-the-mouse-ear-dermis/ Tue, 19 Mar 2013 00:00:00 +0100 PhD Melody A. Swartz, Esra Güç, PhD Witold W. Kilarski There is no crime without clues. They may be obvious, like a cartridge case at the scene of the crime or clear signs of crowbar damage on a door. But sometimes, clues are microscopically small. Besides the classic fingerprints, perpetrators also leave hairs or fiber traces. http://www.leica-microsystems.com/science-lab/forensics/every-clue-counts-forensics-inconceivable-without-microscopy/ Thu, 07 Mar 2013 00:00:00 +0100 M. A. Janika Wiesner The human nervous system is an infinitely complex network consisting of some 100 billions of neurons. It is the result of many-faceted evolutionary processes spanning millions of years which, like the development of other organ systems, have been little researched so far. http://www.leica-microsystems.com/science-lab/molecular-developmental-biology-norwegian-marine-research-scientists-solve-the-mysteries-of-evolution/ Tue, 12 Feb 2013 00:00:00 +0100 Dr. Andreas Hejnol, M. A. Janika Wiesner One hundred years ago, in 1913, the Optische Werke Ernst Leitz in Wetzlar, predecessor of Leica Microsystems CMS GmbH, made two inventions that were to blaze the trail for modern microscopy: the binocular tube and the integrating stage for quantitative microscopy. http://www.leica-microsystems.com/science-lab/history/100-years-of-binoculars-and-quantitative-microscopy/ Thu, 03 Jan 2013 00:00:00 +0100 Rolf Beck Modern image analysis systems perform highly sophisticated image processing functions on images from an automated microscope and digital camera. 50 years ago, the first image analysis system was analogue, based on a video camera and the area measurements could be read from a meter. Nevertheless, it marked the beginning of automation in this field. http://www.leica-microsystems.com/science-lab/history/50-years-of-image-analysis/ Mon, 19 Nov 2012 00:00:00 +0100 Geoff Jenkinson, Kerstin Pingel Nobody is the same. Whether large or small, well- or slightly built, left- or right-handed, everyone has different demands of the tool they work with for many hours a day. This is particularly true of laboratory workstations, where routine tasks such as pipetting or microscope or microtome work require a static posture. http://www.leica-microsystems.com/science-lab/body-in-balance/ Fri, 16 Nov 2012 00:00:00 +0100 John Ludescher, Kerstin Pingel In exploring how embryos take shape, John Wallingford has identified a key pathway involved in vertebrate development – and human disease. http://www.leica-microsystems.com/science-lab/taking-the-long-view/ Tue, 11 Sep 2012 00:00:00 +0200 John B. Wallingford, Karen Hopkin Many people know Germany’s most famous forensic biologist, Dr. Mark Benecke from Cologne, from TV documentaries showing how crimes are solved. Benecke is a welcome guest on talk shows on topics such as forensic trace analysis, murder or the depths of the human psyche in general. He also enjoys an excellent international reputation. However, Mark Benecke’s normal working day bears little resemblance to the scenes shown in TV crime drama series. http://www.leica-microsystems.com/science-lab/even-insect-fragments-throw-light-on-how-crimes-are-committed-how-forensic-biologist-dr-mark-benecke-gains-insights/ Mon, 03 Sep 2012 00:00:00 +0200 Dr. Mark Benecke, M. A. Janika Wiesner “We have to take your fingerprints.” This sentence is spoken in nearly every TV crime drama to a suspect sitting in the interrogation room. But what exactly is it that makes a fingerprint so valuable for detectives in real life? How do fingerprint experts, known as dactyloscopists, perform their jobs? http://www.leica-microsystems.com/science-lab/how-a-fingerprint-is-traced-to-the-person-who-made-it-interactive-microscope-system-facilitates-dactyloscopist-training/ Mon, 13 Aug 2012 00:00:00 +0200 Dieter Kauer, M. A. Janika Wiesner