Webinar: Imaging the Sustainable Cell

September 27, 2012

Sustainability is a hot topic. Disposing of and recycling what we no longer need is critical, and this is true down at the cellular level as well. Cells have a variety of mechanisms for dealing with macromolecules and organelles that are no longer necessary, and when these mechanisms do not function properly, the outcome can be toxic. In some instances the cell itself is no longer necessary; multicellular organisms must dispose of such cells properly to minimize the impact on the surrounding cellular environment. Pathways and processes across biology connect to at least one of the cell's sustainability programs, which include the ubiquitin-proteasome pathway, autophagy, and cell death.

Find out how your work fits into the picture in this webinar – organized by Cell Press and sponsored by Leica Microsystems – where Doug Green, Ana Marie Cuervo, and Ivan Dikic will discuss some of their recent findings and how they look for signs of sustainability (or lack thereof).

Register now and view the webinar on demand:

Imaging the Sustainable Cell

 

 

Who should attend?

This webinar is for any biologist interested in learning about how cells balance resources and make the decision between redirecting resources and initiating death. It will be a great opportunity to learn how the experts are studying these processes and how you can monitor and image each process.

Speakers

 

Douglas Green

Doug Green is the Peter C. Doherty Endowed Chair of Immunology at St Jude Children's Research Hospital. Prior to this he was Head of the Division of Cellular Immunology at the La Jolla Institute for Allergy and Immunology. Doug received his PhD in Biology and Immunology from Yale University. His research has focused on the process of apoptosis and other forms of active cell death. His research extends from the role of cell death in the regulation of cancer and immune responses in the whole organism to the fundamental molecular events directing the death of the cell. He has published over 450 papers, chapters, and books, and is an ISI "highly cited" investigator. His most recent book is "Means to an End: Apoptosis and Other Cell Death Mechanisms," published in 2011 by Cold Spring Harbor Laboratory Press and available at Amazon.

 

Ana Maria Cuervo

Ana Maria Cuervo is the Robert and Renee Belfer Chair for the Study of Neurodegenerative Diseases, Professor in the Departments of Developmental and Molecular Biology and of Medicine of the Albert Einstein College of Medicine and co-director of the Einstein Institute for Aging Studies. She obtained her M.D. degree and a Ph.D. in Biochemistry and Molecular biology from the University of Valencia (Spain) in 1990 and 1994, respectively, and received postdoctoral training at Tufts University, Boston. In 2002, she started her laboratory at the Albert Einstein College of Medicine, where she continues her studies in the role of protein-degradation in neurodegenerative diseases and aging.

Dr. Cuervo’s group is interested in understanding how altered proteins can be eliminated from the cells. Her group has recently linked alterations in lysosomal protein degradation with different neurodegenerative diseases including Parkinson’s, Alzheimer’s and Huntington’s disease. They have also proven that restoration of normal lysosomal function prevents accumulation of damaged proteins with age, demonstrating this way that removal of these toxic products is possible.

Dr. Cuervo is considered a leader in the field of protein degradation in relation to biology of aging and has been invited to present her work in numerous national and international institutions, including among others the Robert R. Konh Memorial Lecture, the NIH Director’s Lecture and the Roy Walford Endowed Lecture. She has organized and chaired international conferences on protein degradation and on Aging, belongs to the editorial board of scientific journals in this topic and she is currently co-Editor-in-Chief of Aging Cell and associate editor of Autophagy. She was the recipient of the 2005 P. Benson Award in Cell Biology, the 2005/8 Keith Porter Fellow in Cell Biology, the 2006 Nathan Shock Memorial Lecture Award, the 2008 Vincent Cristofalo Rising Start in Aging Award, the 2010 Bennett J. Cohen award in basic aging biology and the 2011 Marshall Horwitz Prize for excellence in resesearc. She is currently co-Editor-in-Chief of Aging Cell, associate editor of Autophagy, and member of the NIH/NIA Scientific Council.

 

Ivan Dikic

Ivan Dikic grew up in Croatia, where he trained as a medical doctor. He obtained his PhD in molecular biology from the University of Zagreb while working under the supervision of Joseph Schlessinger at New York University Medical Center. He was a group leader at the Ludwig Institute for Cancer research in Uppsala, Sweden. Ivan Dikic is currently Director of the Buchmann Institute for Molecular Life Sciences and Chair of the Institute of Biochemistry at the Goethe University in Frankfurt, Germany.

He studies ubiquitin (Ub), a small protein that is covalently attached to thousands of cellular proteins thus regulating a myriad of cellular phenotypes. His pioneering work explained how ubiquitin signals are decoded within the cells to mediate appropriate cell functions. He identified more then dozen of Ub-binding domains and used structural and functional studies to demonstrate their roles in the regulation of DNA repair, inflammation, receptor endocytosis and proteasomal degradation. His current interests focus on the role of ubiquitin in selective autophagy, which is essential for the clearance of protein aggregates, pathogens, and damaged mitochondria from the cell.

His recent recognitions and awards include the election in the German Academy Leopoldina (2010) and EMBO (2004), ERC Advanced grant 2010, the Hans Krebs Prize 2010, and the American Association for Cancer Research Award for Outstanding Achievement in Cancer Research in 2006.

 

Moderator

 

Sabbi Lall

Editor Cell Press

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