The classification no more includes granular renal cell carcinoma as this phenotype is part of several tumor types mentioned above. Even spindle cell renal cell carcinoma has been cancelled as an entity, as spindle cells are part of the dedifferentiation process which can develop in all types of renal carcinomas.
All kidney tumor types express a specific immunohistological marker profile and show a distinct histogenesis. While clear cell carcinomas and papillary carcinomas are thought to derive from the proximal tubule, oncocytomas and chromophobe carcinomas are related to the collecting duct as it is expressed in the term for collecting duct carcinoma too.