Leica LMD6000

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Laser microdissection system

Leica LMD6000 - Experience a New Level of Speed

Overview

Experience a New Level of Speed - Laser Microdissection

Contamination-free, fully automated laser microdissection system for targeted cell isolation simply using gravity and a UV diode laser.
Single cells or groups of cells can be microdissected from tissue sections, biopsies, smears, cytospins, and cell cultures. The laser can be also applied for intracellular and cellular ablation. Nucleic acids and proteins specifically isolated from the dissected specimens can be directed to molecular analyses such as: sequencing, genotyping, PCR, real-time PCR, 2D gel electrophoresis or MALDI.
The laser microdissection system is based on the fully automated upright research microscope Leica DM6000 B, the ideal combination for laser microdissection.

Key Features

  • High-speed Laser Microdissection - The fastest way from tissue section to reaction buffer
  • New Diode laser for highest cutting speed, power and precision
  • Automated multi well positioning and well inspection function
  • Multi slide holder for higher productivity
  • Automated cell detection and collection SW
  • Cutting over all magnifications in one step
  • High precision systems – When every µm counts
  • Scanning Stage precision of 2 µm repositioning
  • Auto focus
  • Serial section cutting
  • Laser movement by optics not by mechanics
  • Specially developed, wide range of objectives and automated CCIC (1.25x – 150x)
  • Integrated solution for everybody’s needs
  • Automated Fluorescence
  • Non-contact stress-free preparation
  • Transport by gravity (upright microscope)
  • No mechanical or physical forces are needed
  • Live cell-cutting module
  • Downstream service concept
  • Worldwide service and support organization with full remote control via Internet

Experience a New Level of Speed!
Laser Microdissection has become an indispensable technology for sample preparation. In all areas of research, it is the basic prerequisite to obtain well-defined starting material for downstream experiments. Therefore, meaningful analyses in the fields of genomics, micro arrays, biochips, and proteomics can only be attained with the help of such high-precision technology. Sample preparation is done directly from the tissue section using a UV laser.
The development of both the method and the instruments has made enormous progress during the past five years. Now as before, the driving force in this market is the Leica Microdissection system.
Control the microscope from any position
The new Leica STP6000 SmartTouch Panel can be used to completely and conveniently control the microscope from any position at the laboratory workstation. All automated functions can be set intuitively from the external control panel. The SmartTouch Panel also offers a focus wheel for fine and coarse adjustment, controls for x,y stage adjustments, and eleven programmable function buttons. This provides easy, convenient control of all functions with just one module.
High-speed Microdissection - The fastest way from tissue section to reaction buffer
Time is usually the most critical factor in specimen preparation. Extremely short handling times combined with maximum collection rates result in an unsurpassed speed of cell selection. The isolated material then falls directly into the lysis buffer and thus is protected from degradation.
Intelligent sample preparation – Just a mouse click away
Thanks to the automated cell recognition and laser cutting, sample isolation requires just a few mouse clicks. You can store all the experiment’s parameters and reuse them again and again. This makes Microdissection fun – even for thousands of cells.
Thanks to improved optics and precision laser control, the Leica LMD6000 enables high- precision, high-velocity collection of very small objects, like individual cells. Owing to optical laser control, table movements do not influence the quality of the results. Even chromosomes can be easily cut – the new precision system is equipped with up to 150 x magnification.
High precision systems – When every µm counts
The new laser ensures outstanding cutting quality at all objective magnifications. The scanning stage enables the repositioning of the selected cells with micrometer accuracy. This, along with our patented optical laser control system, renders the collection of even the smallest specimens possible - with maximum precision and at high speeds.
Diode lasers with excellent beam profile and high-power density enable simple and precise processing of all specimen types: because of the latest developments in laser technology, even thick and hard specimens can be easily cut with the powerful diode laser.
Integrated solution for everybody’s needs
Laser Microdissection is a technology that can be used in many fields of life science research. Due to its modular concept, the system is very flexible: we offer you a variety of standard configurations. Thus you can profit from the versatility of the system and choose a solution that is perfectly tailored to your requirements. The integrated scanning stage with a slide holder for up to three specimens, as well as the automated cell recognition, provide higher sample throughput in shorter time.
An additional advantage for material with fluorescent labels is the automated fluorescence module