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Laser Microdissection LMD

Laser Microdissection, also known as LMD or LCM (Laser Capture Microdissection), is a contact- and contamination-free method for isolating specific single cells or entire areas of tissue from a wide variety of tissue samples. The thickness, texture and preparation technique of the original tissue are relatively unimportant. The dissectate is then available for further molecular biological methods such as PCR, real-time PCR, proteomics and other analytical techniques. Laser microdissection is now used in a large number of research fields, e.g. neurology, cancer research, plant analysis, forensics or climate research. The method is meanwhile also applied for manipulation of cell cultures or for microengraving of coverslips.

Our LMD Systems are perfect tools to optimize DNA-Workflows (Genomics), RNA-Workflows (Transcriptomics) and Proteomic-Workflows as they allow to precisely define and collect pure starting material for analysis under visual control.

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Please contact us if you would like to have personal expert advice on our microscopy solutions for laser microdissection.

Leica LMD6500 & LMD7000 Light Microscopes Leica Leica Microsystems

Laser Microdissection Systems Leica LMD6500 & LMD7000

The Leica Laser Microdissection System LMD6500

The LMD6500 is the classic solution for fast, reliable, contact- and contamination-free extraction of desired microscopic samples.

The Leica Laser Microdissection System LMD7000

The Leica LMD7000 has the most powerful and ajustable laser for microdissection of all kinds of tissue and in addition to all options of the LMD6500 the LMD7000 is also able to easily cut hard plant material up to wood of several 100 µm.

Dedicated dry objectives for laser microdissection (5x – 150x)

Example: Laser Microdissection of a mouse aorta.

Frozen section (10 μm) of a mouse aorta (whole vessel) before (A) and after (B) Laser Microdissection stained with cresyl violet on a POL frame slide. Cap inspection allows identification of the dissected section in collector (C). Courtesy of K. Beuerlein, Rudolf-Buchheim-Institut fur Pharmakologie, Justus-Liebig-Universitat Giessen.