Join us at mmc2025
Learn how you can make new discoveries in your research with our latest innovative imaging systems.
- Discover the power of 3D high-plex imaging across scales with SpectraPlex: 15+ markers in one go!
- Uncover deeper cellular insights by combining THUNDER with spinning disk confocal in the new THUNDER Imager Cell Spinning Disk
- Illuminate life in its entirety: explore deep, long-term imaging with Viventis Deep
- Redefine precision sectioning with the UC Enuity ultramicrotome for EM sample prep
- Learn how to harness the power of AI to efficiently and accurately analyze your data with Aivia
JOIN US!
Microscience Microscopy Congress 2025
Leica Microsystems Booth #119
Exhibit Dates: July 1-3, 2025 | Manchester, UK
Deeper spatial insights powered by AI
Book your personal session with our Aivia experts at mmc2025.
- Explore the powerful tools in Aivia AI Image Analysis Software for extracting more meaningful insights from high multiplex imaging experiments.
- Get a personalized demonstration of the SpectraPlex for STELLARIS, and Aivia, workflow.
NEW PRODUCT PRESENTATIONS!
More convincing, high-quality data with the power of THUNDER and spinning disk confocal
Tuesday July 1st, 2025 | 14:00-14:30
Workshop Room 1
Speakers:
Dr Annalisa Rizza, Advanced Workflow Specialist, Leica Microsystems
In this workshop, we will introduce the new THUNDER Imager Cell Spinning Disk, which allows high-speed, high-resolution imaging with reduced phototoxicity. While spinning disk alone provides fast, versatile, confocal imaging and powerful optical sectioning, its new synergistic pairing with THUNDER eliminates residual out-of-focus light, resulting in greater contrast and resolution. This enables you to extract more statistically significant data from diverse 3D samples in less time and with reduced phototoxicity. We will demonstrate this using a practical example of 3D human urothelium organoids. We will also introduce the intelligent automation features of the THUNDER Imager Cell Spinning Disk, including Adaptive Immersion and SmartCORR. Finally, we will discuss how combining this with Aivia for AI-based image analysis can streamline workflows, improve image quality, and deliver more reproducible results.
Precision sectioning redefined: bringing ultramicrotomy to the digital age
Wednesday July 2nd, 2025 | 10:15-10:45
Workshop Room 1
Speaker:
Dr Frederic Leroux, Advanced Workflow Manager, Leica Microsystems
We will introduce the Leica UC Enuity ultramicrotome, a revolutionary advancement in electron microscopy sample preparation. Building on its predecessors' strengths, it features integration of automated setup functions, including auto-alignment of the block face and knife, and auto trimming. These significantly reduce the time and expertise required for sample preparation, making high-quality sectioning accessible to users of all skill levels. The UC Enuity’s modular design is fully upgradable, allowing it to evolve with the user's needs and technological advancements. A new is its ability to utilize micro-CT based 3D trimming, which precisely targets specific regions within a sample, using 3D micro-CT data to guide the trimming process. This innovative approach saves time, reduces sample loss and minimizes the need for extensive user training.
SpectraPlex: overcoming the high multiplexing barrier, increasing throughput and powering discovery
Wednesday July 2nd, 2025 | 13:15-13:45
Workshop Room 1
Speakers:
Dr Emmanuelle Steib, Advanced Workflow Specialist, Leica Microsystems
Join us to explore the experimental design and considerations for performing high multiplexing imaging experiments beyond 15+ fluorophores on a single sample on the STELLARIS platform. Topics include appropriate fluorophore panels, sample preparation, and the challenges and tools required for imaging. We will show how imaging high multiplexing targets on a single sample in one go (one round of labeling and imaging) can be exploited for 3D spatial omics analysis. Furthermore, we will discuss how AI-based image analysis using Aivia software enables robust and efficient analysis of high multiplexing imaging data, providing powerful tools to extract meaningful insights from complex spatial biology experiments.
Can you Beat AI?
Test your cell counting skills against the AI-assisted cell counting capabilities of our Mateo FL Digital Fluorescence microscope! If your estimate is within 10% of the actual count, you'll earn a "Cell Counting Champ" pin and enjoy unlimited bragging rights among your peers!
Visit booth 119 to join the fun!
Next Gen STELLARIS - Discover the power of 3D high-plex imaging across scales
The next generation STELLARIS confocal platform with SpectraPlex allows you to significantly expand your spatial discoveries across scales! Discover new cell types, identify cell states, and map functional relationships in a spatial context to understand disease progression and identify potential therapeutic targets.
With a fully integrated 3D spatial imaging and analysis workflow (in combination with Aivia), it is no longer necessary to have a dedicated additional instrument to acquire multiplexed images that require cumbersome steps to analyze information from high-multiplexed samples.
The next generation STELLARIS allows you to:
- Access 3D spatial information with 15+ markers in one go: Expand captured information across scales
- Design your experiment in advance: Explore and optimize panel options with the integrated functionalities
- Manage data with minimal human interaction: Get intelligent guidance for setting up acquisition and performing the experimental controls
Can’t wait to learn more? Sign up to receive a reminder for our mmc2025 product workshop on July 2nd.
THUNDER Imager Cell Spinning Disk: Clarity Through Synergy
The new THUNDER Imager Cell Spinning Disk combines the benefits of spinning disk confocal with the power of THUNDER. While spinning disk alone provides fast and powerful optical sectioning, applying THUNDER eliminates residual out-of-focus light for greater contrast and resolution, unlocking even more details.
Streamline your workflows with intelligent automation including SmartCORR motorized correction objective lenses, Adaptive Immersion water dispenser, and Sample Finder!
See how you can:
- Combine spinning disk confocal with THUNDER for greater contrast: for more convincing, high-quality data.
- Get fast, versatile, confocal imaging: obtain more statistically significant data from diverse and challenging 3D samples faster.
- Streamline workflows with intelligent automation: boost your productivity by focusing on your experiment, rather than your system.
Don’t miss your chance to learn more! Sign up to receive a reminder for our mmc2025 product workshop on July 1st.
Composite image of rat brain stained with Hoechst (red), CPCA (cyan), Fox3/Neun and RPCA (magenta). Image acquired using the THUNDER Imager Cell Spinning Disk with a 40x plan apo objective over 30 individual fields of view. Sample courtesy of EnCor Bioimaging inc.
Viventis Deep - Revealing life in its full context
The Viventis Deep light sheet fluorescence microscope combines multi-view and multi-position light-sheet imaging to illuminate life in its entirety. Begin your journey to discover deep, long-term imaging that reveals the intricate details and dynamics of biological systems.
Viventis Deep enables you to:
- Explore life in depth: expand the spatio-temporal understanding of your sample to its full-depth
- Explore multiple living samples in parallel: the open-top configuration enables higher throughput and multi-position capabilities
- Explore life events with long-term imaging: the gentle light sheet provides high image quality while preserving sample viability.
Aivia: Get to insights faster and easier powered by AI
Using state-of-the-art, AI-first software architecture, Aivia is a uniquely innovative and complete 2-to-5D image visualization, analysis and interpretation platform designed for the reliable processing and reconstruction of highly complex images in just minutes.
- Accurately segment 2D and 3D cells by simply painting using Segment by Example
- Achieve quantitative insights easier with Aivia Launchpad, tutorial guides, and pre-set Guided Sequences
- Complete analysis workflow from cell detection to phenotyping to data exploration for multiplexed images
- Automated cell detection and tracking offer more precise and consistent analysis in time-lapse images
- Leverage novel tools to explore and visualize complex data and spatial relationships
Book your personal session with our Aivia experts at mmc2025
Large Volume Computational Clearing (LVCC)-processed THUNDER image of a human pancreatic islet organoid labeled with insulin (green). Cells segmented using the Segment By Example tool in Aivia. Image courtesy of the Matthias von Herrath Lab, La Jolla Institute of Immunology, La Jolla, CA.
