The Leica SR GSD is based on GSDIM technology (Ground State Depletion followed by Individual Molecule return) which provides the highest resolution, down to 20 nm, possible with a light microscope today.
One of the key advantages of the GSDIM method is that it can be used with conventional fluorescence labels routinely applied in fluorescence imaging applications.
To prevent drift during image acquisition the Leica SR GSD is equipped with the novel SuMo Stage technology (SUpressed MOtion).
http://the-scientist.com/2012/01/01/top-ten-innovations-2011/
