Science Lab

Science Lab

Science Lab

Willkommen auf dem Wissensportal von Leica Microsystems. Hier finden Sie wissenschaftliches Forschungs- und Lehrmaterial rund um das Thema Mikroskopie. Das Portal unterstützt Anfänger, erfahrene Praktiker und Wissenschaftler gleichermaßen bei ihrer täglichen Arbeit und ihren Experimenten. Erkunden Sie interaktive Tutorials und Anwendungshinweise, entdecken Sie die Grundlagen der Mikroskopie ebenso wie High-End-Technologien. Werden Sie Teil der Science Lab Community und teilen Sie Ihr Fachwissen.
AI-based inspection detects, classifies, and measures defects directly in microscope images of components.

AI Image Analysis for Reliable Defect Detection

AI-based visual inspection with microscopy helps make quality control in industrial environments efficient by reducing manual inspection effort concerning defect detection, classification, and…
Overview of Artificial Intelligence (AI) and Machine Learning

An Overview of Artificial Intelligence (AI) and Machine Learning

AI is rapidly changing industrial inspection, quality control, and manufacturing workflows. But not all AI technologies work the same way. From machine learning and deep learning to the newer concept…
Why the Future of Microscopic Inspection Is AI-Assisted, Not Fully Automated

Why the Future of Microscopic Inspection Is AI-Assisted, Not Fully Automated

The next wave of QC productivity gains will not come from building more automated inspection lines. Instead, it will come from augmenting millions of inspection decisions that are made manually every…
Particle analysis with the Visoria M microscope

AI-Based Particle Counting with the Aivaro AI Feature Detection Software Module

The Aivaro AI Feature Detection software module enables fast manual microscope inspection of particulate contamination on various material samples. By training different classes, reflective particles,…
High-resolution 3D optics [JB19.1]with enhanced depth of field [JB20.1]allow surgeons to clearly identify and safely dissect perforators and perform delicate vessel anastomoses. Mr Dariush Nikkhah. DIEP surgery London.

DIEP Flap Breast Reconstruction: Microsurgical Visualization

DIEP flap breast reconstruction is an autologous microsurgical procedure that depends on precise vessel dissection, anastomosis and perfusion assessment [1]. This article discusses how surgical…
Cryo-confocal fluorescence imaging of the milled lamella on the TEM grid after cryo-FIB preparation. Residual fluorescence signal confirms that the targeted region of interest—containing malaria parasite structures—has been successfully retained during lamella preparation, supporting accurate correlation between cryo-fluorescence microscopy and cryo-electron microscopy workflows.

Fluorescence-Guided Cryo-ET of Malaria Parasites

Correlative cryo workflow with cryo-planing and cryo-fluorescence imaging enables targeted cryo-ET of parasite-rich regions in complex tissue.
Serial Lift-Out workflow for cryo-ET lamella preparation - Schematic illustration of the Serial Lift-Out method applied to a vitrified biological sample (e.g., C. elegans larva) embedded in bulk vitreous ice (blue). Image courtesy: Prof. Dr. Jürgen M. Plitzko - doi.org/10.1038/s41592-023-02113-5.

Cryo-ET Sample Preparation: From Waffle Method to Serial Lift-Out

Cryo-ET sample preparation becomes more demanding when specimens are thicker, larger, or more complex. This webinar brings together four perspectives on how high-pressure freezing can be connected…
Fixed patient-derived neuroendocrine tumor organoids labeled with DAPI (cyan) and phalloidin (magenta), imaged using Viventis SCAPE; scale bar 50μm. Courtesy of Marina Cuenca and Heleen Jungen (Dayton lab), EMBL Barcelona.

What’s the Best Organoid Imaging Approach for Early Drug Discovery?

Organoids and other complex in vitro models (CIVMs) are becoming increasingly important in early drug discovery and translational research, driven by the need for more predictive, human-relevant data…
Waffle method lamella preparation and cryo-ET results - Representative workflow and results of lamella preparation from a vitrified C. elegans L1 larva using the waffle method. Image courtesy: Prof. Dr. Jürgen M. Plitzko - doi.org/10.1038/s41592-023-02113-5-

Waffle Method Workflow: From HPF to Cryo-ET Lamellae

Waffle freezing provides an HPF-based route to cryo-ET sample preparation. This workflow guide follows the process from grid and carrier assembly to vitrification, cryo-FIB milling, lamella…
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