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Leica EM Sample Preparation Workflows

Leica Microsystems offers reliable and easy-to-handle workflows for a large variety of samples in the fields of materials research, life science research, medical research, industrial manufacturing, and natural resources. Our solutions enable researchers to address their greatest challenges: from preserving cells in their near-native state to preparing artefact-free semiconductor cross-sections.

Every single step in our sample preparation solutions is aligned to this approach.

Get in touch with our Team of Experts

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Your work is like our solutions: Unique!

Each workflow solution consists of several instruments that are perfectly geared to one another. In total we offer a broad range of highly innovative products that give you sustainable benefits:

  • Most precise results
  • Automated workflows
  • Time saving
  • Cost saving
  • Reliability and reproducibility
  • Safe handling
  • Improved productivity

See for instance how our Smart Solution for Remote Monitoring of our Freeze Substitution system can help you optimize your work in your lab:

Remote Monitoring for Leica EM AFS2

Our Fields of Expertise

We offer EM sample preparation methods, from standard ultramicrotomy to Cryo-Preparation, that are designed to meet the highest demands in technology and handling.

"All instruments we offer are developed to integrate seamlessly, so that the workflow runs smoothly. Our team of product managers and application experts works closely together to ensure one instrument best matches the other," Ian Lamswood, Marketing Director with Leica Microsystems.

  • Ultramicrotomy & Cryo-Ultramicrotomy
  • Freeze Fracture EM Coating
  • Cryo Transfer
  • Plunge Freezing
  • Cryofixation
  • High Pressure Freezing
  • Ion Beam Milling
  • Target Preparation - mechanical grinding and polishing
  • EM Embedding
  • EM Tissue Processing
  • Critical Point Drying Freeze Substitution
  • EM Contrasting
  • High Pressure Freezing

Be prepared for great results

Excellent Sample Preparation is a prerequisite for perfect microscopy.

Explore Science Lab – the online platform for learning, sharing and discussing Sample Preparation topics. Browse through the growing lists of articles, become part of the community and take the opportunity to contribute.

Some of our latest articles:

Leica Microsystems offers the most comprehensive product portfolio for the preparation of biological, medical and industrial samples.


Slope cut of gold wire bonding

Industrial Manufacturing

Cross section of painted concrete

Natural Resources

Cross section of oil shale

Life Science Research

High-pressure frozen Cerebellar slice of mouse brain

Most recent additions to our Product Portfolio

Our products allow perfect preparation of samples for examination in the Electron Microscope (TEM – Transmission Electron Microscope and SEM – Scanning Electron Microscope), LM (Light Microscope), Confocal Microscope and AFM (Atomic Force Microscope).

For information about our full range of products in EM Sample Preparation, please visit our Website.

Leica EM ICE

High Pressure Freezer with optional Light Stimulation

Leica EM Cryo CLEM

Correlating Cryofixed Biological Samples in the Light- and Electron Microscope

Leica EM ACE900

High-End EM Sample Preparation Freeze Fracture System