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Super-Resolution Microscopes and Nanoscopes

Super-resolution microscopes and nanoscopes overcome the diffraction limit of light and allow investigators to study subcellular structures in greater detail than achieved with a standard confocal microscope. With the possibility of resolutions down to 30 nm with STED as well as sub-cellular dynamics can be studied at the nanoscale.

Sub-diffraction colocalization analysis reveals interactions unprecedented detail. Enabling novel discoveries to be made in the fields of virology, immunology, neuroscience and cancer, super-resolution is on its way to becoming the new gold standard in light microscopy.

Explore life’s true nature in unprecedented detail.

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LIGHTNING

LIGHTNING

The maximum of information from each specimen

News

SP8 LIGHTNING confocal microscope

08. April 2019 Next generation confocal platform for super-resolution live cell imaging in multicolor

Detailed observations of fast biological processes with the SP8 LIGHTNING

11. October 2017 White Blood Cell Recruitment to Bacterial Infection

Zebrafish In Vivo Study Using Leica Fluorescence Microscopes

Tile scan image of Mouse brain tissue section with multicolor immunofluorescent labeling

23. May 2017 Find the Missing Links in Advanced Live Cell Research - Leica launches DMi8 S live cell imaging solution

Wetzlar, Germany – Leica introduces the DMi8 S, a new complete solution designed to give researchers the ultimate tool for fast, versatile microscopic...

11. April 2017 Full Spectral Freedom for Multi-color Deep Tissue In Vivo Imaging

Leica Microsystems launches SP8 DIVE – The World's First Tunable Deep Imaging Solution

01. November 2016 Explore life’s true nature with super-resolution and nanoscopy

With HyVolution 2 and the Leica TCS SP8 STED ONE, Leica Microsystems paves the way to access imaging beyond the diffraction limit

21. May 2015 GSD Around the World – A Travel Diary on Facebook

Tamara Straube and Peter Laskey will take you on a journey around the world: Together with a team of specialists, they visited 10 countries, organized...

13. March 2015 EMBL Advanced Course – Intensive Super-Resolution Microscopy Course for Localization Microscopy and STED

From 20th to 25th July 2015 the EMBL (European Molecular Biology Laboratory), Heidelberg will be holding a six-day intensive course on the subject of...

19. January 2015 New Leica TCS SP8 at Bates College: „Second of its kind in Maine, new microscope is a game-changer“

According to Bates College, the confocal offers new imaging capabilities and supports research in biology, neuroscience, nanotechnology and...

03. December 2014 Free Infographic: Which Super-Resolution Microscopy Method is Right for You?

This illustrated guide to super-resolution microscopy helps you compare technologies to best fulfill your individual research needs.

The Leica TCS SP8 STED 3X was chosen among The Scientist Top 10 Innovations 2014

01. December 2014 The Scientist Top 10 Innovations Award for Leica TCS SP8 STED 3X

Leica Microsystems’ STED Super-Resolution Microscope Again Awarded for its Innovative Technology

13. February 2019 Extending Nanoscopy Possibilities with STED and exchangeable fluorophores

When it comes to STED Nanoscopy, keeping high signal-to-noise is key to achieve the best possible resolution in fixed and living cells. This can be…

05. December 2018 Webinar: See More Than Just Your Image

Despite the emergence of new imaging methods in recent years, true 3D resolution is still achieved by Confocal Laser Scanning Microscopy (CLSM).…

01. December 2018 Dynamic Endoplasmic Reticulum

The Endoplasmic Reticulum (ER) is a dynamic, reticular or net-like structure consisting of tubules and cisternae that extend throughout the cell and…

13. November 2018 Simultaneously Measuring Image Features and Resolution in Live-Cell STED Images

Reliable interpretation and quantification of cellular features in fluorescence microscopy requires an accurate estimate of microscope resolution.…

19. September 2018 How to extract Image Information by Adaptive Deconvolution

Confocal Laser Scannning Microscopy (CLSM) is the standard for true 3D resolved fluorescence imaging. Fast optical sectioning using flexible scanning…

30. August 2018 Observing Malaria Infection at the Right Spot in the Human Host

Malaria is a life-threatening disease transmitted through the bites of mosquitoes infected with protozoan parasites. The most common and dangerous…

23. August 2018 Direct visualization of the arterial wall water permeability barrier using CARS microscopy

The artery wall is equipped with a water permeation barrier that allows blood to flow at high pressure without significant water leak. The precise…

07. August 2018 Free Webinar On-Demand: Super-resolved STED spectroscopy

Molecular interactions are key in cellular signalling. They are often ruled or rendered by the mobility of the involved molecules.

06. July 2018 STED Nanoscopy at the forefront of cancer research

Alison Dun is the postdoctoral facility manager for the Edinburgh Super-Resolution Imaging Consortium (ESRIC), Heriot-Watt University, Edinburgh, UK.…

05. June 2018 Researchers Find a “Digital” Mechanism Behind Neuronal Changes from Learning

Neurons react to learning and memory by activating synaptic connections. The mechanisms behind this fundamental process are complex and poorly…