Emily M. Mace , Ph.D.
Emily Mace was born in Victoria, BC, Canada and completed her Bachelor’s of Science at the University of Saskatchewan, Saskatoon, Canada. She received her Ph.D. in Genetics from the University of British Columbia in Vancouver, Canada where under the supervision of Dr. Fumio Takei at the BC Cancer Research Center (Terry Fox Laboratory) she studied the mechanism of integrin activation in murine natural killer cells. She is currently a postdoctoral fellow in the laboratory of Dr. Jordan Orange at the Children’s Hospital of Philadelphia Research Institute, where she uses high resolution and super resolution microscopy to investigate the role of the cytoskeleton in human NK cell function. Her other interests include NK cell development and primary immunodeficiency.
Human NK Cell Development Requires CD56-mediated Motility and Formation of the Developmental Synapse
While distinct stages of natural killer (NK) cell development have been defined, the molecular interactions that shape human NK cell maturation are poorly understood. Here we define intercellular…Read article
Lytic Immune Synapse Function Requires Filamentous Actin Deconstruction by Coronin 1A
Natural killer (NK) cells are cytolytic effector cells of the innate immune system. Here, we show that deconstruction of synaptic cortical filamentous (F)-actin by Coronin 1A (Coro1A) is required for…Read article
Visualization of the Immunological Synapse by Dual Color Time-gated Stimulated Emission Depletion (STED) Nanoscopy
Here we illustrate the protocol for imaging by two-color STED nanoscopy the cytotoxic immune synapse of NK cells recapitulated on glass. Using this method we obtain sub-100 nm resolution of synapse…Read article
Visualization of the Natural Killer Cell Immune Synapse by Super-Resolution Nanoscopy
Natural killer (NK) cells are innate immune effectors that recognize and kill virally infected and tumorigenic cells. Central to their effector function is the formation of an immunological synapse…Read article
Dual Channel STED Nanoscopy of Lytic Granules on Actin Filaments in Natural Killer Cells
Natural killer (NK) cells are innate immune effectors that eliminate diseased and tumorigenic targets through the directed secretion of specialized secretory lysosomes, termed lytic granules. This…Read article