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Alexander Ernst , Dr.

Alexander Ernst

Alexander Ernst obtained his master’s degree in cell biology and bioinformatics in 2016 at the Technical University of Braunschweig, Germany. He studied the role of the cytoskeleton in neuronal migration by confocal imaging in vivo in the group of Prof. Reinhard Köster. In the same year, he moved to the Institute of Anatomy, University of Bern Switzerland and started a specialized PhD program for cutting edge microscopy at the University of Bern. In his PhD project, carried out in the group of Prof. Nadia Mercader, he investigated the development of the heart in the zebrafish by live imaging, using confocal and light sheet microscopy. For his work he obtained the best thesis prize from the Swiss Society of Anatomy. After completing his PhD in 2020, he joined a project investigating the role of Covid-19 on the cardiovascular system and performed a drug screening with zebrafish embryos utilizing automated microscopy and Deep Learning-based image analysis. Since July 2021, he is supporting microscopy and image analysis applications at the Institute of Anatomy in Bern, Switzerland.

Wt1b-positive myocardial cell adopting an epicardial cell morphology.

Wt1 Genes Can Induce a Cardiomyocyte to Epicardial-like Cell Fate Transition

From this study, it was concluded that Wt1 plays a yet undescribed role for cardiomyocyte differentiation by repressing chromatin opening at specific genomic loci and that sustained ectopic expression…
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