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Carl A. Ascoli, PhD

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Carl A. Ascoli graduated from the University of Medicine and Dentistry of New Jersey in 1988.  Working with Dr. Gerd Maul at the Wistar Institute, he identified a novel nuclear structure called PML bodies which serve as a storage depot for various regulatory proteins. He is the Chief Science Officer for Rockland Immunochemicals and has more than 30 years of academic and industrial expertise in virology, immunology, host-agent interaction, autoimmune diseases, cancer biology, antibody production and engineering, protein purification and recombinant technology.

http://www.rockland-inc.com/chief-science-officer.aspx

  • Localization of HDAC1 Using Super-Resolution STED Microscopy

    Here we show staining of HDAC1 in cancer tissue and epidermoid carcinoma cells. These results clearly show that the use of appropriate validated antibodies and STED microscopy are important tools to study subcellular structures beyond the diffraction limit correcting ill-defined images. This is critical in co-localization studies of proteins inside cells.
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  • Subcellular Localization of AKT and Tubulin using Super-Resolution Microscopy

    Stimulated Emission Depletion microscopy, or STED nanoscopy, is a technique that uses the non-linear de-excitation of fluorescent dyes to overcome the resolution limit imposed by diffraction encountered with standard confocal laser scanning microscopes and conventional far-field optical microscopes[1]. Compared to traditional confocal microscopy, STED offers exceptional improvements in resolution allowing visualization of cellular events at unprecedented levels.
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