Mark Benecke was born in Rosenheim, Germany. After receiving a Dr. rer. medic. at Cologne University in 1997, he worked in the Chief Medical Examiner's Office in Manhattan, New York from 1997–1999. Since 1995, he has been working internationally on forensic cases as a freelance expert witness. He also teaches at various police academies and acts as a visiting professor to universities in Germany, England, Vietnam, Colombia, and the Philippines.
Benecke has published several popular science books about the biology of aging, criminal cases and forensic biology. He is a member of the editorial board of the Annals of Improbable Research, Cambridge, USA, guest editor for Forensic Science International (Forensic Entomology Special Issue) and scientific advisor to the German skeptic organization GWUP, where he publishes skeptical articles on various topics.