Prof. DrSc. Pavel Hozák is the head of the Microscopy Centre of the Institute of Molecular Genetics, Academy of Sciences of the Czech Republic in Prague.
A cell and molecular biologist, Pavel studied Biology at the Moscow State University, followed by research posts at the Dunn School of Pathology, Oxford University and at the Institute of Experimental Medicine of the Czechoslovak Academy of Sciences. Since 2006, he has been Head of the Department of Biology of the Cell Nucleus and since 2015, also Head of the Microscopy Centre, both at the Institute of Molecular Genetics of the Academy of Sciences of the Czech Republic. He publishes in leading journals including Cell, Nature Cell Biology and Science. He lectures at the Charles University in the field of cellular and molecular biology, medical biology and microscopy. He is also the national coordinator of Czech-BioImaging and Euro-BioImaging.
Major research topics:
Definition of higher-order structures in the cell nucleus; mechanisms forming nuclear compartmentalization
Structure, dynamics, and function of the nucleoskeleton
Identification of nuclear structures active in epigenetic regulation of gene expression
Characterization of nuclear functions of myosin I, actin and actin-binding proteins
Localization and function of nuclear phospholipids in chromatin functions
Development of new methods in microscopy
In the Department of Cellular Biology Department of the Institute of Molecular Genetics of the ASCR, Prof. Hozák has long been involved in research related to the cell nucleus, particularly in the patterns governing genome functioning, because their disruption leads to an imbalance in gene activity and serious disease. Among the important discoveries of Prof. Hozák’s team, it has been found that the reading of genes is aided by myosin protein molecules and some lipids. His team also works towards improving electron microscopy methods that shift the possibilities of scientific research into cell structure. Prof. Hozak patented a set of nanoparticles of different shapes to make it possible to recognize the location of different molecules in cells, otherwise impossible with standard nanoparticles used.