Ralf Jacob studied biology at the University of Düsseldorf, Germany and received his Ph.D. degree in Cell Biology in November 1994. He stayed in the laboratory of Prof. Hassan Naim at the Department of Microbiology in Düsseldorf as postdoctoral fellow for the following year, where he worked on the biosynthesis, processing and sorting of membrane proteins in epithelial cells. As lab head in the Pharma-Research Centre of Bayer AG in Wuppertal he established new screening technologies from 1995 to 1997. Thereafter he was recruited as a group leader in the Department of Biochemistry at the School of Veterinary Medicine in Hanover to continue his work in Prof. Hassan Naim's lab. In 2003 he was appointed to the Philipps University of Marburg.