Contact & Support
Header Image

Serge Mostowy, PhD

serge-mostowy-sl.jpg

Serge Mostowy studied Physics, Evolution, and Microbiology & Immunology at McGill University in Canada. After postdoctoral work on the Cell Biology of Infection at Institut Pasteur in France, he moved to Imperial College London in 2012 to start a Wellcome Trust Research Career Development Fellowship. His lab is now part of the MRC Centre of Molecular Bacteriology and Infection, where he investigates novel roles for the cytoskeleton in innate immunity.

Serge also developed the zebrafish as an important model to study the cell biology of infection and therapeutic potential of targeting the cytoskeleton in vivo. His findings should be of considerable interest for both cell biologists and infection biologists, and make a cutting edge platform for in vivo studies both at the single cell and whole animal level. Serge is a Wellcome Beit (2012), Lister Institute of Preventive Medicine (2015), and Wellcome Trust Senior Research Fellow (2017).

  • Real Time Observation of Neutrophil White Blood Cell Recruitment to Bacterial Infection In Vivo

    The zebrafish (Danio rerio) is an emerging vertebrate model organism to study infection. The transparent larva comprises a fully functional innate immune system and enables live imaging of fluorescent immune cells in transgenic animals. Zebrafish infection models have been developed for both the human bacterial pathogen Shigella flexneri and the natural fish bacterial pathogen Mycobacterium marinum. Importantly, whilst S. flexneri causes acute infection and is typically used as an inflammatory paradigm, M. marinum causes a chronic disease similar to tuberculosis in humans. Here, we use real time fluorescence microscopy to image transgenic zebrafish larvae with neutrophils (granulocyte white blood cells) expressing the green fluorescent protein eGFP.
    Read article