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Daniel Studer

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Daniel Studer is a graduate of ETH-Z (Federal Institute of Technology Zurich, Switzerland) and was collaborator at the central Electron Microscopy facility of ETH from 1982 to 1992. He then became group leader at the Maurice E. Müller Institute of Biomechanics at the University of Bern, where he investigated the ultrastructure of cartilage (1992–2001). Daniel Studer then moved to the Institute of Anatomy at the University of Bern (2001- present) where he worked on characterizing the ultrastructure of osteoblastic cell cultures, in collaboration with Jeff Gorski. He also worked with Michael Frotscher on the ultrastructure of the hippocampus. As a senior lecturer he teaches medical science students.

Daniel Studer was mainly interested in improving cryomethods for electron microscopy. He invented the prototype Leica-EM PACT high pressure freezer and the microbiopsy system of Leica-microsystems, Vienna, Austria. In addition he invented, with the help of Diatome, Biel, Switzerland, the oscillating diamond knife for ultrathin sectioning. For the latter he received the Ernst Ruska Prize of the Deutsche Gesellschaft für Elektronenmikroskopie in 2005.

  • Safe High Pressure Freezing of Infectious Microorganisms

    Especially in core EM-facilities one is confronted with material (microorganisms and cells) which are infectious. It is a must to follow the safety rules according to the National regulations. However even when safe laboratories are available it is very convenient to know that the applied high pressure freezing system is in itself safe.
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  • Dry Ultrathin Sectioning Combined With High Pressure Freezing

    We have used cultured UMR106-01 osteoblastic cells to investigate the process of bone mineralization. UMR106-01 cells as well as primary calvarial bone cells assembly spherical extracellular supramolecular protein-lipid complexes, termed biomineralization foci (BMF), in which the first crystals of hydroxyapatite mineral are deposited (Midura et al., 2004; Wang et al., 2004). A major difference between these culture models is the speed with which mineralization occurs, ranging from 12–16 days after plating for primary osteoblastic cells to 88 h for UMR106-01 cells.
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