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Philip Tinnefeld, Prof.


Philip Tinnefeld is Professor of Biophysical Chemistry at the Institute of Physical & Theoretical Chemistry, at the Braunschweig Integrated Center for Systems Biology (BRICS), and at the Laboratory for Emerging Nanometrology (LENA), Braunschweig University of Technology. He studied chemistry in Münster, Montpellier (France), and Heidelberg (Germany). In 2002, he received his PhD from the University of Heidelberg. He carried out postdoctoral research with S. Weiss (UCLA), F. C. de Schryver (KU Leuven, Belgium) and M. Sauer (Bielefeld) on the development of single molecule fluorescence microscopy. After habilitation in physics at Bielefeld University and three years as associate professor of biophysics at Ludwig-Maximilians-Universität Munich, he was appointed full professor of biophysical chemistry at Braunschweig University of Technology in 2010.
His research is inspired by our emerging abilities to study and built matter bottom-up, starting from single molecules. He has contributed to the breakthroughs of single-molecule Super-Resolution microscopy by discovering the switchability of commercially available fluorescent dyes such as Cy5 and by discovering the reducing and oxidizing system (ROXS). He was involved in the development of three Super-Resolution techniques including dSTORM, Blink Microscopy and DNA PAINT.
In recent innovations, he combined optical single-molecule detection with DNA nanotechnology for self-assembled molecular devices with optical readouts including energy transfer switches, calibration nanorulers, nano-adapters, optical signal amplifiers and molecular force balances.
Dr. Tinnefeld has authored more than 130 publications and patents. He has been initiator and mentor of GATTAquant GmbH, the first company commercializing a DNA origami application. Among several awards are the Chemistry prize of the Göttingen Academy of Science, a Schloessmann Award of the Max-Planck-Society, and an ERC starting grant.