Jeff P. Gorski , Ph.D.

Jeff P. Gorski

Professor Jeff Gorski is a graduate of the McArdle Laboratory for Cancer Research, University of Wisconsin-Madison.  He did postdoctoral training in molecular immunology at Scripps Clinic and Research Foundation and was a faculty member at the Mayo Clinic Medical School and Director of the Orthopaedic Biochemistry laboratory at Mayo prior to moving to the University of Missouri-Kansas (UMKC), Kansas City in 1987. 

While at UMKC, he has been a member of the Schools of Biological Sciences (1987-2004) and Dentistry (2004-present). Dr. Gorski has spent yearlong sabbaticals at the University of Minnesota (1981-1982) and at Harvard Medical School (1997-1998), along with extended research visits at Merck Research Labs (West Point, PA), the National Institute of Dental Research-NIH (Bethesda, MD), Cleveland Clinic and Research Foundation (Cleveland, OH), and University of Bern (Bern, Switzerland). 

Jeff is presently a member of the Bone Biology Program, the Center of Excellence in Mineralized Tissues, and a Professor in the Department of Oral Biology. He has mentored three M.Sc. students at Mayo and two Ph.D. students and one M.Sc. student at UMKC; served on over 30 Ph.D. committees; advised over 35 medical and dental student research projects; and, sponsored two visiting faculty research sabbaticals.

Throughout this time, Professor Gorski has carried out research on thioester containing complement protein C4 and anaphlatoxin C4a, matrix metalloproteinases and proprotein convertases in bone and teeth, and the role of bone extracellular matrix phosphoproteins in the initial differentiated events of primary bone formation and mineralization. 

This externally funded research has been multidisciplinary in nature incorporating electron microscopy and high pressure freezing, laser capture microscopy, confocal raman spectroscopy, tandem mass spectrometry, as well as proteomic, transgenic, and cell culture approaches.  In many cases, such as the work described here, Dr. Gorski’s laboratory, in collaboration with key collaborators, has developed new methods within these fields to advance his research interests.

Dry Ultrathin Sectioning Combined With High Pressure Freezing

We have used cultured UMR106-01 osteoblastic cells to investigate the process of bone mineralization. UMR106-01 cells as well as primary calvarial bone cells assembly spherical extracellular…
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