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Jen-Yi Lee , PhD

Jen-Yi Lee

Jen-Yi Lee holds a Ph.D. in Molecular and Cell Biology from the University of North Carolina, Chapel Hill, USA, where she specialized in cell movements during C. elegans development. She went on to do postdoctoral research at the University of California, Berkeley, where she studied morphogenesis of Xenopus laevis. After taking a brief break from the bench, Jen returned to the University of California, Berkeley as a staff scientist, where she helped manage 20 light microscopes at a imaging core facility, and supported University researchers through teaching and consultation. She has been working at Leica Microsystems as an applications specialist since 2017.

Raw widefield and THUNDER image of Drosophila follicles. Image courtesy of M. Khoury and D. Bilder, University of California, Berkeley, USA.

Investigating Epithelial Morphogenesis and the Growth of Epithelia

This article shows how rapidly acquired THUNDER images of Drosophila follicles or egg chambers help distinguish apicobasal proteins when studying epithelial morphogenesis for cancer research.
Images of C2C12 cells which were stained with lamin B (magenta), Hoechst (blue), and yH2AX (yellow). A) raw widefield fluorescence image and B) THUNDER image after LVCC. The yellow foci indicate damaged DNA.

Skeletal Muscle Adaptation and Fibrotic Diseases

The mechanisms of how skeletal muscle adapts to fibrotic pathologies can be investigated more efficiently with fast, high-contrast imaging of C2C12 mouse myoblast cells which is described in this…
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