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  • Brighter Fluorescence by Resonant Scanning

    Fast True Confocal Scanning reduces photobleaching and increases the fluorescence yield at identical acquisition times. The long-lasting triplet state (or any other “dark state”) is less populated when the illumination is applied in shorter pulses at the same intensity. Consequently, more fluorochromes are available for the fluorescence process (brighter images) and fewer fluorochromes disintegrate from triplet states or excited triplet states (less bleaching).
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  • Find the Needle in the Haystack

    The obvious has been explored. These days, biologists strive to identify and analyze hidden and rare events. The task is tackled by automatically screening large numbers of objects – typically growing in multi-well plates – over a long period of time. When an interesting feature is identified (manually or by means of computed recognition), modern systems can automatically monitor and record these events at high resolution.
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  • Unlimited Resolution - STED

    STED uses a differential method of two different diffraction patterns, where one pattern excites and the second pattern de-excites fluorochromes. The residual excited area is controllable by intensity down to (theoretically) zero – unlimited resolution.
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  • Pinhole Controls Optical Slicing

    True confocal scanning microscopes (TCS) use a variable detection pinhole. Good optical sectioning tries to use just the inner core of the PSF.
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  • Confocal Optical Section Thickness

    Confocal microscopes are employed to optically slice comparably thick samples.
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  • Lasers for Confocal

    True confocal scanning microscopy (TCS) requires bright diffraction-limited illumination.
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  • Integrated Modulation Contrast (IMC)

    Hoffman modulation contrast has established itself as a standard for the observation of unstained, low-contrast biological specimens. The integration of the modulator in the beam path of themodern inverted microscopes allows a wide range of brightfield or phase objectives to be used, rather than a small selection of special objectives.
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  • Koehler Illumination

    This tutorial demonstrates the basic steps for setting up a correct illumination of specimen with transmitted (and reflected) light.
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  • Confocal Microscopy

    “Confocal Microscopy” refers to a particular optical microscope that allows recording optical sections. Optical sectioning is achieved in a confocal system by illuminating and observing a single diffraction limited spot.
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  • One of Our Last Horizons

    An insight into the unknown world of the deep sea was given in an exhibition staged by the Senckenberg Society together with the Natural History Museum in Basel, Switzerland. Shown in Frankfurt am Main and Berlin, Germany, the "Deep Sea" exhibition was a huge public success in 2009. From May to September 2010, the exhibition has been shown in the Natural History Museum in London. Scientists of the Senckenberg Society work with stereomicroscopes and digital cameras both in the laboratory and on the research ships.
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  • Mapping Billions of Synapses with Microscopy and Mathematics

    A combination of widefield imaging techniques and image segmentation analysis enable researchers to map learning-induced functional changes in individual synapses throughout the hippocampus.
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  • Users Report on the Relevance of Laser Microdissection for Their Research Results

    Laser dissection is used in a large number of research fields, e.g. neurology, cancer research, plant analysis. Here, user report on the research results they have attained by using laser microdissection.
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  • Good Vibrations

    In recent years, new molecular imaging techniques, such as coherent anti-Stokes Raman scattering microscopy (CARS), have been developed for rapid vibrational imaging of living cells.
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  • Webinar: High Pressure Freezing and Follow-on Techniques for Research Biology

    A part of the success in understanding the complexity of biological processes depends on appreciating the connection between structure, function and time.
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  • Exploring the Concert of Neuronal Activities

    Brain research using Confocal and Multiphoton Microscopy. Using imaging techniques such as confocal and two-photon microscopy, neuronal dendritic arborization of neurons and their synaptic interconnections can be visualized.
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  • Deep Tissue Imaging

    Developmental biology using Multiphoton microscopy with OPO. To gain new insight into the fundamental control of cell response to physical changes and to study the dynamics and roles of biological flow during the development of the zebrafish, Dr. Julien Vermot established his lab last year at the Institute of Genetics and Molecular and Cellular Biology (IGBMC) in Strasbourg, France.
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  • CARS and Confocal

    The most important drawback of single-photon and multiphoton confocal microscopy is the need to label the specimen. CARS (Coherent Anti-Stokes Raman Spectroscopy) addresses this issue because it is non-toxic, non-destructive, and minimally invasive.
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  • Sniffing Out the Secrets of Social Behavior

    Yet we are only just beginning to understand the complexities and functional differences of the sense of smell in mammals. Prof. Marc Spehr, head of the Department of Chemosensation at RWTH Aachen University since 2009, explains his findings on the neuronal mechanisms of olfactory perception and signal processing using the mouse model. He and his team are trying to find out how substances for social interaction are perceived and how this perception generates a specific type of behavior.
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  • Restless Receptors

    Synapses are the switch-points in our brain for information transmission, learning and memory. News studies and developments of imaging techniques have provided new insights into the dynamics of glutamate receptors. The use of superresolution technologies is making an essential contribution to this research.
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  • What is an OPO?

    Multiphoton microscopy with OPO: imaging with excitation wavelengths up to 1.300 nm. Because light scattering is dependent on the wavelength, better tissue penetration can be achieved by using longer excitation wavelengths. This is where excitation with infrared light, two-photon processes, and the OPO (optical parameter oscillator) can dramatically improve image quality.
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  • Webinar: The Solution for Deep Imaging

    Imaging of thick specimen using multiphoton microscopy. Multiphoton microscopy is the method of choice for non-invasive deep-penetration fluorescence microscopy of thick highly scattering samples. Good results have already been obtained with a diversity of specimen, e.g. lymphatic organs, kidney, heart, skin and brain (slices as well as whole organs, fixed specimen as well as living cells).
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  • Wilhelm Fabry – Surgeon, Inventor, and Publicist

    Before academic education for medical practitioners became the norm, barber-surgeons treated wounds and performed minor operations as members of the tradesmen’s guild as late as the end of the 16th century. The surgeon Wilhelm Fabry, born in Hilden in 1560, Germany, was not content with this classification of his profession, however.
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  • State-of-the-Art Microscope Enables New Vitreoretinal Surgery Technique

    In pars plana vitrectomy, three ocular incisions are normally made. Thanks to the superb optics and the unique illumination concept of the Leica M844 F40, Dr. Luca Cappuccini from Reggio Emilia Hospital in Italy can operate without one of the incisions for certain vitreoretinal procedures. This shortens the duration of surgery and speeds up eye recovery time.
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  • Making the Finest Blood Vessels Visible

    Cerebrovascular disease, which can be triggered or result from a ruptured aneurysm, is the third most common cause of death in industrial countries and the main cause of severe long-term disability and the need for lifelong care. Dr. Joaquim Enseñat, neurosurgeon at the Clinic de Barcelona Hospital in Spain, has used the technique of intraoperative video-angiography with the Leica FL800 fluorescence module to treat cerebral aneurysms since 2008.
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  • Webinar: Vitreous Thin Film Preparation for Cryo-Transmission Electron Microscopy

    Are you interested in preparing vitreous thin-film samples from biological components, macromolecules, microtubules, cosmetics, polymers, paints, liposomes, for analysis in the cryo transmission electron microscope?
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