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  • State-of-the-Art Microscope Enables New Vitreoretinal Surgery Technique

    In pars plana vitrectomy, three ocular incisions are normally made. Thanks to the superb optics and the unique illumination concept of the Leica M844 F40, Dr. Luca Cappuccini from Reggio Emilia Hospital in Italy can operate without one of the incisions for certain vitreoretinal procedures. This shortens the duration of surgery and speeds up eye recovery time.
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  • Making the Finest Blood Vessels Visible

    Cerebrovascular disease, which can be triggered or result from a ruptured aneurysm, is the third most common cause of death in industrial countries and the main cause of severe long-term disability and the need for lifelong care. Dr. Joaquim Enseñat, neurosurgeon at the Clinic de Barcelona Hospital in Spain, has used the technique of intraoperative video-angiography with the Leica FL800 fluorescence module to treat cerebral aneurysms since 2008.
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  • Webinar: Vitreous Thin Film Preparation for Cryo-Transmission Electron Microscopy

    Are you interested in preparing vitreous thin-film samples from biological components, macromolecules, microtubules, cosmetics, polymers, paints, liposomes, for analysis in the cryo transmission electron microscope?
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  • Steel – the All-Rounder That Has to Pass Many Tests

    Steel is a real all-rounder. However, each application requires a specifi c sort of steel grade. Without steel there would be no Olympic stadiums, wind energy plants, bridges, skyscrapers, trains, planes, cars, razor blades or knives for medical and home use – at least, not of the quality and design we know today. Buderus Edelstahl GmbH in Wetzlar, Germany is one of the world’s top producers of special steel.
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  • How Sharp Images Are Formed

    In microscopy, depth of field is often seen as an empirical parameter. In practice it is determined by the correlation between numerical aperture, resolution and magnification. For the best possible visual impression, the adjustment facilities of modern microscopes produce an optimum balance between depth of field and resolution – two parameters which in theory are inversely correlated.
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  • Intraocular Lenses

    Only a few decades ago, the diagnosis ‘cataracts’ meant loss of vision in the near future. Today, cataract surgery is the most common operation worldwide.
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  • Precision That Saves Eyesight

    Retina surgery demands experienced surgeons and precision technology. In vitreoretinal surgery, the surgeon operates with microscissors and forceps that are less than a millimeter thick. The Swiss company Alcon Grieshaber is one of the world’s leading specialists in handheld instruments for minimally invasive eye surgery.
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  • Webinar: Amplify the Power of Imaging

    High Content Screening (HCS) is the answer to the change from descriptive to quantitative fluorescence imaging in life sciences research.
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  • Confocal Nanoscopy Goes Multicolor

    Scientists strive to understand the architecture of life. They want to learn how biological structures are arranged in respect to one another. Multicolor superresolution imaging allows fundamental questions to be addressed by far-field fluorescence microscopy in unprecedented detail.
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  • Antique Underwater Treasures Endangered

    In the 2nd century BC, Baiae in the Gulf of Naples was a notorious bathing resort and spa for wealthy Romans. Today, part of the town is submerged under the sea and can be visited as an 80,000 square metre archaeological underwater park. The magnificent mosaics from the underwater ruins are analysed at the Istituto Superiore per la Conservazione e il Restauro (ISCR) of the Ministry for Cultural Heritage and Activities in Rome.
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  • Restoring Former Glory with Cotton Buds and a Microscope – The Princely Collections of Liechtenstein

    On her way to work, Ruth Klebel is often approached by tourists asking for the times of guided tours. She always gives the same answer before disappearing behind the wide automatic gate: “I’m afraid there aren’t any, this is private property.” As a restorer of the collections of the Prince of Liechtenstein, Klebel is one of the very few people who regularly come and go at Vaduz Castle without actually living here.
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  • Ancient Feast of Color

    Everyone knows that antique marble sculptures were white. Or were they? Scientists of the Copenhagen Polychromy Network (CPN) help to show that the statues of the Greeks and Romans were decorated with extravagant ornaments and sumptuous colours. With the help of a surgical microscope and digital microscopy, the conservators detect tiny traces of paint pigment that suggest a veritable feast of colour in ancient times.
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  • Cochlea Implants for the Deaf and Severely Hard of Hearing

    People who can’t hear are outsiders, cut off from normal conversation. Children born into a silent world never learn to talk. Adults who lose their hearing due to age, accident or illness are no longer able to participate in social life as they did before and are moreover often branded as slow-witted. Prof. Dr. med. Jan Maurer, Senior Consultant of the ENT clinic and Medical Director of the Catholic Hospital of Koblenz, Germany, has specialised, among other things, in special hearing implants such as the cochlea implant, and post-implantation rehabilitative therapy.
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  • Ergonomics in Ophthalmic Surgery

    Every operation demands a maximum of concentration from the surgeon and his team. A comfortable, pain-free working posture helped by the ergonomic design of the surgical microscope aids concentration – and contributes significantly to the success of the operation. Andrew Morris, Consultant Ophthalmologist at the Royal Bournemouth Hospital, England since 2002, reports on his experience with ergonomics in everyday working life.
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  • The Mitochondrial Hypothesis of Ageing

    Why do we grow old? Research scientists have been looking for an answer to this question for many years – particularly against the background of the increase in neurodegenerative diseases among older people such as Morbus Parkinson.
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  • Just What the Surgeon Wants

    We’ve all experienced an everyday product at some time that had great technology and a stylish design but was totally impractical to use. A designer coffee pot that spills its contents all round the cup or a mobile phone with such tiny keys that you can’t help pressing two at once. If instruments for medical professionals were designed with so little regard for practical application, they’d have no chance of surviving on the market.
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  • Seeing Without a Haze – Trends in Cataract Surgery

    Cataract surgery has been practised for centuries and is one of the most common operations performed worldwide today. Ultra modern surgical techniques with tiny incisions and high-quality prosthetic lenses make the operation extremely safe and yield excellent results. Nevertheless, cataract surgery is being perfected all the time.
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  • Fluorescence-guided Resection of Malignant Glioma – Only Red-fluorescing Areas Excised

    For resection of brain tumours in particular, neurosurgeons are faced with the same dilemma time and again: how to remove the tumour completely without ­destroying neurological functions. Nowadays, surgeons harness the possibilities of intraoperative fluorescence technology for exact and full excision of tumour tissue so that the patient’s quality of life can be saved or even enhanced.
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  • Digital Cameras

    Manufacturers digital cameras race to outdo each other with ever-increasing numbers of megapixels. The world record for professional medium format digital cameras has now surpassed 60 megapixels per shot using a very large and expensive sensor with a resolution of about 9000 x 6700 pixels. Each time you capture such an image you get about 180 MB of uncompressed data and even more if you switch to 16-bit per colour for full dynamic range.
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  • Steel – It All Depends on What's Really Inside

    Steel, an alloy of iron and carbon, is both stable and elastic, extremely resistant, and a permanent item in our everyday life. Today there are over 2,500 standard steel types, with new grades and applications emerging all the time. Each steel type is specially made for its purpose. It is subject to stringent quality standards to ensure that it optimally withstands the specific loads.
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  • New Standard in Electrophysiology and Deep Tissue Imaging

    The function of nerve and muscle cells relies on ionic currents flowing through ion channels. These ion channels play a major role in cell physiology. One way to investigate ion channels is to use patch clamping. This method allows investigation of ion channels in detail and recording of the electric activity of different types of cells, mainly excitable cells like neurons, muscle fibres or beta cells of the pancreas. The patch clamping technique was developed by Erwin Neher and Bert Sakmann in the 1970s and 80s to study individual ion channels in living cells. In 1991 they received the Nobel Prize for Physiology and Medicine for their work. Today the patch clamping technique is one of the most important methods in the field of electrophysiology.
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  • Observing Life’s Nanostructures with STED

    The secrets of life and the causes of many diseases can only be fully explained if we understand the functions of the smallest components of organisms. Using the super high resolution STED microscope, research scientists are now able to observe cellular proteins and molecular structures measuring only a few nanometres.
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  • In Vivo Labeling Method Using a Genetic Construct for Nanoscale Resolution Microscopy

    We demonstrate beam scanning-stimulated emission depletion microscopy with in vivo labeled cells. A red emitting fluorescent dye is introduced into membrane protein fused to a multifunctional reporter protein (HaloTag, Promega, Madison, WI) in live cells. This approach allows superresolution stimulated emission depletion imaging without the limitations of immunofluorescence-based staining.
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  • Research for the Optimal Structure

    To see how liquids can be made to flow, without being directly heated or touched, you only have to watch a raw egg explode in a microwave oven. Electromagnetic forces can even melt metal at hotter than 1000 °C. In the Magnetohydrodynamics study group at the Research Centre Dresden-Rossendorf (FZD) these complex interactions between electrically conductive liquids and magnetic fields are used to control the flow and solidification processes of liquid metal alloys.
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