Leica Center of Excellence at UCLA

Leica Center of Excellence at UCLA

The California NanoSystems Institute (CNSI) is a hub of interdisciplinary research, translation, and education, where scientists from diverse fields find common purpose in addressing challenges of the 21st century. With locations at the University of California’s Los Angeles and Santa Barbara campuses, the CNSI drives collaborative research across disciplines, translates discoveries into knowledge-driven commercial enterprises, and educates the next generation of scientists and engineers. The Institute leverages an unprecedented public-private partnership to provide students and entrepreneurs with an infrastructure and progressive training that foster innovation to sustain California’s economic competitiveness in the global marketplace.

The Advanced Light Microscopy/Spectroscopy laboratory at CNSI provides a collection of high-end, customized instruments for fluorescence imaging including confocal microscopes and  small-animal pre-clinical imagers to perform fluorescence-based imaging and measurements at various spatial (nm to cm), temporal (ns to days) and spectral (UV-NIR) ranges for the study of macromolecules, cellular dynamics and biomaterials with nanometer-accuracy.

"The Leica CoE provides CNSI with the cutting-edge technology needed to advance our research in biophotonics and its application to the imaging of tissues, cells, subcellular structures and biological molecules." -Laurent A. Bentolila, PhD

2nd image: STED HeLa Cells. Two-color STED nanoscopy on a HeLa Cell monolayer grown on a coverslip: green is alpha-tubulin labelled with Chromeo 594 and red is Histone K4me3 labelled with Atto 647N. Courtesy of Laurent A. Bentolila, UCLA, United States.

Related Information

Website: https://cnsi.ucla.edu/facilities/technology-centers/alms/

Leica News: UCLA and Leica establish center of excellence in microscopy at CNSI

Areas of Application: Cell biology • Human cell culture • Organelles • Cytoskeleton • Tubulin network • Nucleus • Chromatin • Super-resolution • STED • Nanoscopy

Recommended Reading

Wet Chemical Synthesis
In Situ Shape Control of Thermoplasmonic Gold Nanostars on Oxide Substrates for Hyperthermia-Mediated Cell Detachment
Download pdf "Wet Chemical Synthesis"

Protein Regulation
Proteoglycans regulate protein tyrosine phosphatase receptor σ organization on hematopoietic stem/progenitor cells
Download pdf "Protein Regulation"

Tumor Growth Inhibition
Physical activity modulates mononuclear phagocytes in mammary tissue and inhibits tumor growth in mice
Download pdf "Tumor Frowth Inhibition"

Antimicrobial TH17 Cells
Extracellular traps released by antimicrobial TH17 cells contribute to host defense
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