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Laser Microdissection Publication List

Laser microdissection is a relatively new technique, having first been developed in the 1990s. It makes it possible to obtain homogenous, ultrapure samples from heterogenous starting material. A researcher can selectively and routinely analyze regions of interest down to single cells to obtain results that are reproducible, and specific. Laser microdissection uses a microscope to visualize individual cells or cell clusters. Regions of interest are selected by software, excised from the surrounding tissue by a laser, and collected by gravity into specialized devices for analysis. This references list is monthly updated and presents current papers in the major application fields for laser microdissection.

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Table of Content

DNA Research

Overexpression of MTH1 and OGG1 proteins in ulcerative colitis‑associated carcinogenesis
Kumagae Y, Hirahashi M, Takizawa K, Yamamoto H, Gushima M, Esaki M, Matsumoto T, Nakamura M, Kitazono T, Oda Y
Oncology Letters, 0, 0-0. doi.org/10.3892/ol.2018.8812

Prevalence and molecular characteristics of DNA mismatch repair protein-deficient sebaceous neoplasms and keratoacanthomas in a Japanese hospital-based population
Kuwabara K, Suzuki O, Chika N, Kumamoto K, Minabe T, Fukuda T, Arai E, Tamaru JI, Akagi K, Eguchi H, Okazaki Y, Ishida H
Jpn J Clin Oncol. 2018 Apr 28. doi: 10.1093/jjco/hyy055.

Detection of human parvovirus B19 infection in the thymus of patients with thymic hyperplasia-associated myasthenia gravis
Gong L, Li Y, Li X, Tu Q, Mou X, Wang S, Wan Y, Lu Q, Wang J, Zhang W, Zhu S, Han X, Yao L, Zhang J, Huang G, Zhang W
Clin Microbiol Infect. 2018 Apr 9. pii: S1198-743X(18)30298-2. doi: 10.1016/j.cmi.2018.03.036.

RNA Research

The aberrantly expressed miR-372 partly impairs sensitivity to apoptosis in parathyroid tumor cells
Verdelli C, Forno I, Morotti A, Creo P, Guarnieri V, Scillitani A, Cetani F, Vicentini L, Balza G, Beretta E, Ferrero S, Vaira VA, Corbetta S
Endocr Relat Cancer. 2018 May 3. pii: ERC-17-0204. doi: 10.1530/ERC-17-0204.

Urinary miR-196a predicts disease progression in patients with chronic kidney disease
Zhang C, Liang S, Cheng S, Li W, Wang X, Zheng C, Zeng C, Shi S, Xie L, Zen K, Liu Z
J Transl Med. 2018 Apr 10;16(1):91. doi: 10.1186/s12967-018-1470-2.

ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice
Kimura Y, Fukuda A, Ogawa S, Maruno T, Takada Y, Tsuda M, Hiramatsu Y, Araki O, Nagao M, Yoshikawa T, Ikuta K, Yoshioka T, Wang Z, Akiyama H, Wright CV, Takaori K, Uemoto S, Chiba T, Seno H
Gastroenterology. 2018 Mar 28. pii: S0016-5085(18)30346-9. doi: 10.1053/j.gastro.2018.03.039.

Proteomics

Accelerated pre-senile systemic amyloidosis in PACAP knockout mice - a protective role of PACAP in age-related degenerative processes
Reglodi D, Jungling A, Longuespée R, Kriegsmann J, Casadonte R, Kriegsmann M, Juhasz T, Bardosi S, Tamas A, Fulop BD, Kovacs K, Nagy Z, Sparks J, Miseta A, Mazzucchelli G, Hashimoto H, Bardosi A
J Pathol. 2018 May 17. doi: 10.1002/path.5100.

A novel liver metastasis-correlated protein of pancreatic neuroendocrine neoplasm (PanNEN) discovered by proteomic analysis
Shimura M, Mizuma M, Takadate T, Katoh Y, Suzuki T, Iseki M, Hata T, Aoki S, Suzuki Y, Sakata N, Ohtsuka H, Hayashi H, Morikawa T, Nakagawa K, Motoi F, Naitoh T, Igarashi K, Sasano H, Unno M
Oncotarget. 2018; 9:24291-24303.

Tissue-Specific Analysis of Secondary Metabolites Creates a Reliable Morphological Criterion for Quality Grading of Polygoni Multiflori Radix
Liang L, Xu J, Liang ZT, Dong XP, Chen HB, Zhao ZZ
Molecules. 2018 May 8;23(5). pii: E1115. doi: 10.3390/molecules23051115.

Fluorescence Applications

Tissue-Specific Analysis of Secondary Metabolites Creates a Reliable Morphological Criterion for Quality Grading of Polygoni Multiflori Radix
Liang L, Xu J, Liang ZT, Dong XP, Chen HB, Zhao ZZ
Molecules. 2018 May 8;23(5). pii: E1115. doi: 10.3390/molecules23051115.

Upregulation of HDAC2 in Laser Capture Nigral Microglia in Parkinson’s Disease
Tan Y, Delvaux E, Nolz J, Coleman PD, Chen S, Mastroeni D
Neurobiology of Aging, 2018, ISSN 0197-4580, doi.org/10.1016/j.neurobiolaging.2018.02.018.

A novel ex vivo Huntington's disease model for studying GABAergic neurons and cell grafts by laser microdissection
André EM, Daviaud N, Sindji L, Cayon J, Perrot R, Montero-Menei CN
PLoS One. 2018 Mar 5;13(3):e0193409. doi: 10.1371/journal.pone.0193409. eCollection 2018.

Cancer Research

An anatomic transcriptional atlas of human glioblastoma
Puchalski RB, Shah N, Miller J, Dalley R, Nomura SR, Yoon JG, Smith KA, Lankerovich M, Bertagnolli D, Bickley K, Boe AF, Brouner K, Butler S, Caldejon S, Chapin M, Datta S, Dee N, Desta T, Dolbeare T, Dotson N, Ebbert A, Feng D, Feng X, Fisher M, Gee G, Goldy J, Gourley L, Gregor BW, Gu G, Hejazinia N, Hohmann J, Hothi P, Howard R, Joines K, Kriedberg A, Kuan L, Lau C, Lee F, Lee H, Lemon T, Long F, Mastan N, Mott E, Murthy C, Ngo K, Olson E, Reding M, Riley Z, Rosen D, Sandman D, Shapovalova N, Slaughterbeck CR, Sodt A, Stockdale G, Szafer A, Wakeman W, Wohnoutka PE, White SJ, Marsh D, Rostomily RC, Ng L, Dang C, Jones A, Keogh B, Gittleman HR, Barnholtz-Sloan JS, Cimino PJ, Uppin MS, Keene CD, Farrokhi FR, Lathia JD, Berens ME, Iavarone A, Bernard A, Lein E, Phillips JW, Rostad SW, Cobbs C, Hawrylycz MJ, Foltz GD
Science. 2018 May 11;360(6389):660-663. doi: 10.1126/science.aaf2666

A novel liver metastasis-correlated protein of pancreatic neuroendocrine neoplasm (PanNEN) discovered by proteomic analysis
Shimura M, Mizuma M, Takadate T, Katoh Y, Suzuki T, Iseki M, Hata T, Aoki S, Suzuki Y, Sakata N, Ohtsuka H, Hayashi H, Morikawa T, Nakagawa K, Motoi F, Naitoh T, Igarashi K, Sasano H, Unno M
Oncotarget. 2018; 9:24291-24303.

The aberrantly expressed miR-372 partly impairs sensitivity to apoptosis in parathyroid tumor cells
Verdelli C, Forno I, Morotti A, Creo P, Guarnieri V, Scillitani A, Cetani F, Vicentini L, Balza G, Beretta E, Ferrero S, Vaira VA, Corbetta S
Endocr Relat Cancer. 2018 May 3. pii: ERC-17-0204. doi: 10.1530/ERC-17-0204.

Neurosciences

Upregulation of HDAC2 in Laser Capture Nigral Microglia in Parkinson’s Disease
Tan Y, Delvaux E, Nolz J, Coleman PD, Chen S, Mastroeni D
Neurobiology of Aging, 2018, ISSN 0197-4580, doi.org/10.1016/j.neurobiolaging.2018.02.018.

A novel ex vivo Huntington's disease model for studying GABAergic neurons and cell grafts by laser microdissection
André EM, Daviaud N, Sindji L, Cayon J, Perrot R, Montero-Menei CN
PLoS One. 2018 Mar 5;13(3):e0193409. doi: 10.1371/journal.pone.0193409. eCollection 2018.

Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion
Munakata Y, Yamada T, Imai J, Takahashi K, Tsukita S, Shirai Y, Kodama S, Asai Y, Sugisawa T, Chiba Y, Kaneko K, Uno K, Sawada S, Hatakeyama H, Kanzaki M, Miyazaki JI, Oka Y, Katagiri H
Sci Rep. 2018 Jan 24;8(1):1499. doi: 10.1038/s41598-018-19765-5.

Clinical Applications

Accelerated pre-senile systemic amyloidosis in PACAP knockout mice - a protective role of PACAP in age-related degenerative processes
Reglodi D, Jungling A, Longuespée R, Kriegsmann J, Casadonte R, Kriegsmann M, Juhasz T, Bardosi S, Tamas A, Fulop BD, Kovacs K, Nagy Z, Sparks J, Miseta A, Mazzucchelli G, Hashimoto H, Bardosi A
J Pathol. 2018 May 17. doi: 10.1002/path.5100.

Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis
Milani P, Dispenzieri A, Scott CG, Gertz MA, Perlini S, Mussinelli R, Lacy MQ, Buadi FK, Kumar S, Maurer MS, Merlini G, Hayman SR, Leung N, Dingli D, Klarich KW, Lust JA, Lin Y, Kapoor P, Go RS, Pellikka PA, Hwa Yl, Zeldenrust SR, Kyle RA, Rajkumar SV, Grogan M
Circ Cardiovasc Imaging. 2018 May;11(5):e006588. doi: 10.1161/CIRCIMAGING.117.006588.

Apolipoprotein CII amyloidosis associated with p.Lys41Thr mutation
Sethi S, Dasari S, Plaisier E, Ronco P, Nasr SH, Brocheriou I, Theis JD, Vrana JA, Zimmermann MT, Quint PS, McPhail ED, Kurtin PJ
Kidney International Reports (2018), doi: 10.1016/ j.ekir.2018.04.009.

Developmental Research, Epigenetics & Aging

Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons
Telezhkin V, Straccia M, Yarova P, Pardo M, Yung S, Vinh NN, Hancock JM, Barriga GG, Brown DA, Rosser AE, Brown JT, Canals JM, Randall AD, Allen ND, Kemp PJ
Pflugers Arch. 2018 May 24. doi: 10.1007/s00424-018-2155-7.

LCM-seq reveals the crucial role of LsSOC1 in heat-promoted bolting of lettuce (Lactuca sativa L.)
Chen Z, Zhao W, Ge D, Han Y, Ning K, Luo C, Wang S, Liu R, Zhang X, Wang Q
Plant J. 2018 May 17. doi: 10.1111/tpj.13968.

Laminin-332 regulates differentiation of human interfollicular epidermal stem cells
Yamada T, Hasegawa S, Miyachi K, Date Y, Inoue Y, Yagami A, Arima M, Iwata Y, Yamamoto N, Nakata S, Matsunaga K, Sugiura K, Akamatsu H
Mech Ageing Dev. 2018 Mar 16. pii: S0047-6374(17)30259-2. doi: 10.1016/j.mad.2018.03.007.

Plant Research

Tissue-Specific Analysis of Secondary Metabolites Creates a Reliable Morphological Criterion for Quality Grading of Polygoni Multiflori Radix
Liang L, Xu J, Liang ZT, Dong XP, Chen HB, Zhao ZZ
Molecules. 2018 May 8;23(5). pii: E1115. doi: 10.3390/molecules23051115.

Overexpression of the TaSHN1 transcription factor in bread wheat leads to leaf surface modifications, improved drought tolerance and no yield penalty under controlled growth conditions
Bi H, Shi J, Kovalchuk N, Luang S, Bazanova N, Chirkova L, Zhang D, Shavrukov Y, Stepanenko A, Tricker P, Langridge P, Hrmova M, Lopato S, Borisjuk N
Plant Cell Environ. 2018 May 14. doi: 10.1111/pce.13339.

LCM-seq reveals the crucial role of LsSOC1 in heat-promoted bolting of lettuce (Lactuca sativa L.)
Chen Z, Zhao W, Ge D, Han Y, Ning K, Luo C, Wang S, Liu R, Zhang X, Wang Q
Plant J. 2018 May 17. doi: 10.1111/tpj.13968.

Forensics

DNA perspectives of fixed and paraffin embedded human tissues as resource materials for the identification
Ullah S, Garg RK, Noor F
Egyptian Journal of Forensic Sciences (2017) 7:23

Establishing the limit of detection of massively parallel sequencing using laser micro-dissected cells
Nancollis G, England R, Harbison SA
Forensic Science International: Genetics Supplement Series, Sep 2017

Forensic Biology – Expert Evidence
Gunn P, Roebuck H, Summerell A
Bookchapter, reviewed March 2017

Information for practitioners
Helpful information, videos, and many tipps & tricks on laser microdissection in forensic applications can be found here.

Miscellaneous

Toxoplasma gondii TFP1 is an essential transporter family protein critical for microneme maturation and exocytosis
Hammoudi PM, Maco B, Dogga SK, Frénal K, Soldati-Favre D
Mol Microbiol. 2018 May 8. doi: 10.1111/mmi.13981.
dx.doi.org/10.1111/mmi.13981

Oxygen minimum zone cryptic sulfur cycling sustained by offshore transport of key sulfur oxidizing bacteria
Callbeck CM, Lavik G, Ferdelman TG, Fuchs B, Gruber-Vodicka HR, Hach PF, Littmann S, Schoffelen NJ, Kalvelage T, Thomsen S, Schunck H, Löscher CR, Schmitz RA, Kuypers MMM
Nat Commun. 2018 Apr 30;9(1):1729. doi: 10.1038/s41467-018-04041-x.

Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues
Crusco A, Bordoni C, Chakroborty A, Whatley KCL, Whiteland H, Westwell AD, Hoffmann KF
European Journal of Medicinal Chemistry (2018), doi: 10.1016/j.ejmech.2018.04.032.

Live Cell Culture

Long-distance electron transport in individual, living cable bacteria
Bjerg JT, Boschker HTS, Larsen S, Berry D, Schmid M, Millo D, Tataru P, Meysman FJR, Wagner M, Nielsen LP, Schramm A
Proc Natl Acad Sci U S A. 2018 May 7. pii: 201800367. doi: 10.1073/pnas.1800367115.

A novel ex vivo Huntington's disease model for studying GABAergic neurons and cell grafts by laser microdissection
André EM, Daviaud N, Sindji L, Cayon J, Perrot R, Montero-Menei CN
PLoS One. 2018 Mar 5;13(3):e0193409. doi: 10.1371/journal.pone.0193409. eCollection 2018.

miR-182 Regulates Slit2-Mediated Axon Guidance by Modulating the Local Translation of a Specific mRNA
Bellon A, Iyer A, Bridi S, Lee FC, Ovando-Vázquez C, Corradi E, Longhi S, Roccuzzo M, Strohbuecker S, Naik S, Sarkies P, Miska E, Abreu-Goodger C, Holt CE, Baudet ML
Cell Rep. 2017 Jan 31;18(5):1171-1186. doi: 10.1016/j.celrep.2016.12.093.