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Science Lab
Science Lab
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
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![THUNDER image of brain-capillary endothelial-like cells derived from human iPSCs (induced pluripotent stem cells) where cyan indicates nuclei and magenta tight junctions. THUNDER image of brain-capillary endothelial-like cells derived from human iPSCs (induced pluripotent stem cells) where cyan indicates nuclei and magenta tight junctions.](/fileadmin/_processed_/8/e/csm_Brain-capillary_endothelial-like_cells_derived_from_human_iPSCs_b5dcf04bc9.jpg)
Rapid Check of Live Stem Cells in Cell-culture Inserts Set in Multi-well Plates
See how efficient imaging of live iPSC stem cells within cell-culture inserts set in a multi-well plate can be done to evaluate the cells using a THUNDER Imager. Just read this article.
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![Murine esophageal organoids (DAPI, Integrin26-AF 488, SOX2-AF568) imaged with the THUNDER Imager 3D Cell Culture. Courtesy of Dr. F.T. Arroso Martins, Tamere University, Finland. Murine esophageal organoids (DAPI, Integrin26-AF 488, SOX2-AF568) imaged with the THUNDER Imager 3D Cell Culture. Courtesy of Dr. F.T. Arroso Martins, Tamere University, Finland.](/fileadmin/_processed_/f/f/csm_THUNDER_Imager_3D_Cell_Culture_Murine-esophageal-organoid_LVCC_9bc587500f.jpg)
How to Get Deeper Insights into your Organoid and Spheroid Models
In this eBook, learn about key considerations for imaging 3D cultures, such as organoids and spheroids, and discover microscopy solutions to shed new insights into dynamic processes in 3D real-time
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![Single cell datasets Single cell datasets](/fileadmin/_processed_/8/8/csm_Single_cell_datasets_SPARCS_441a58445d.jpg)
Exploring Subcellular Spatial Phenotypes with SPARCS
Discover spatially resolved CRISPR screening (SPARCS), a platform for microscopy-based genetic screening for spatial subcellular phenotypes at the human genome scale.
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![Brain organoid section (DAPI) acquired using THUNDER Imager Live Cell. Image courtesy of Janina Kaspar and Irene Santisteban, Schäfer Lab, TUM. Brain organoid section (DAPI) acquired using THUNDER Imager Live Cell. Image courtesy of Janina Kaspar and Irene Santisteban, Schäfer Lab, TUM.](/fileadmin/_processed_/2/7/csm_Tilescan_of_brain_organoid_section_46d510ba4e.jpg)
Imaging Organoid Models to Investigate Brain Health
Imaging human brain organoid models to study the phenotypes of specialized brain cells called microglia, and the potential applications of these organoid models in health and disease.
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![Mouse cortical neurons. Transgenic GFP (green). Image courtesy of Prof. Hui Guo, School of Life Sciences, Central South University, China Mouse cortical neurons. Transgenic GFP (green). Image courtesy of Prof. Hui Guo, School of Life Sciences, Central South University, China](/fileadmin/_processed_/2/a/csm_THUNDER_Imager_Mouse_cortical_neuron_9d4054774d.jpg)
How Microscopy Helps the Study of Mechanoceptive and Synaptic Pathways
In this podcast, Dr Langenhan explains how microscopy helps his team to study mechanoceptive and synaptic pathways, their challenges, and how they overcome them.
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![Microscopy for neuroscience research Microscopy for neuroscience research](/fileadmin/_processed_/9/5/csm_Microscopy_for_neuroscience_research_cc303ca353.jpg)
What are the Challenges in Neuroscience Microscopy?
eBook outlining the visualization of the nervous system using different types of microscopy techniques and methods to address questions in neuroscience.
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![Cancer cells Cancer cells](/fileadmin/_processed_/6/b/csm_Cancer_cells_0188d06359.jpg)
The Role of Iron Metabolism in Cancer Progression
Iron metabolism plays a role in cancer development and progression, and modulates the immune response. Understanding how iron influences cancer and the immune system can aid the development of new…
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![How is microscopy used in spatial biology? A microscopy guide. How is microscopy used in spatial biology - Teaserimage](/fileadmin/_processed_/0/f/csm_spatial-biology-ebook-tease_5ac6218fa3.jpg)
How is Microscopy Used in Spatial Biology? A Microscopy Guide
Different spatial biology methods in microscopy, such as multiplex imaging, are helping to better understand tissue landscapes. Learn more in this microscopy guide.
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![](/fileadmin/_processed_/3/7/csm_Getting_sharper_3D_images_teaser_dd8f41d6b0.jpg)
Going Beyond Deconvolution
Widefield fluorescence microscopy is often used to visualize structures in life science specimens and obtain useful information. With the use of fluorescent proteins or dyes, discrete specimen…