Science Lab
Science Lab
The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
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Multiplexed Imaging Types, Benefits and Applications
Multiplexed imaging is an emerging and exciting way to extract information from human tissue samples by visualizing many more biomarkers than traditional microscopy. By observing many biomarkers…
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Multiplexed Imaging Glossary
Human tissues contain a many different biomarkers which can be explored to reveal the workings of biological pathways and interrogate disease states. Recent technological advances have made it…
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Tumor MHC Expression and Intralesional IL2 Response in Melanoma
Genomics profiling and Cell DIVE multiplex imaging allows researchers to understand the immune cell phenotypes that most strongly predict response to IL2 immunotherapy in melanoma patients suffering…
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Visualizing the Mitotic Spindle in Cancer Cells
This article demonstrates how this research is aided by visualizing more details of mitotic spindles in Ewing Sarcoma cells using the THUNDER Imager Tissue and Large Volume Computational Clearing…
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Simplifying the Cancer Biology Image Analysis Workflow
As cancer biology data sets grow, so do the challenges in microscopy image analysis. Aivia experts cover how to overcome these challenges with AI.
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Imaging of Anti-Cancer Drug Uptake in Spheroids using DLS
Spheroid 3D cell culture models mimic the physiology and functions of living tissues making them a useful tool to study tumor morphology and screen anti-cancer drugs. The drug AZD2014 is a recognized…
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Designing your Research Study with Multiplexed IF Imaging
Multiplexed tissue analysis is a powerful technique that allows comparisons of cell-type locations and cell-type interactions within a single fixed tissue sample. It is common for researchers to ask…
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Be Confident in your Results with Cell DIVE Validated Antibodies
The Cell DIVE System includes a carefully curated list of hundreds of commercially available antibodies validated to offer optimal specificity and sensitivity in multiplexed imaging. That validation…
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Overcoming Multiplexed Imaging Roadblocks
Whether a single slide or a batch of slides processed on multiple Cell DIVE imagers, every step carried out by the Cell DIVE Acquisition Software eliminates distortions and artifacts and seamlessly…