Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Latest Articles

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How to Quantify Changes in the Metabolic Status of Single Cells

Metabolic imaging based on fluorescence lifetime provides insights into the metabolic dynamics of cells, but its use has been limited as expertise in…

May 27, 2021

Case Study
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Regulators of Actin Cytoskeletal Regulation and Cell Migration in Human NK Cells

Dr. Mace will describe new advances in our understanding of the regulation of human NK cell actin cytoskeletal remodeling in cell migration and immune…

Apr 15, 2021

Webinar
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A Quality Metric for the Systematic Evaluation of Clearing Protocols

3D multicellular spheroids are of interest for studying tumor behavior and evaluating the response of pharmacologically active agents, because they…

Apr 15, 2021

Abstract
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Benefits of TauContrast to Image Complex Samples

In this interview, Dr. Timo Zimmermann talks about his experience with the application of TauSense tools and their potential for the investigation of…

Apr 12, 2021

Interview
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Targeting Active Recycling Nuclear Pore Complexes using Cryo Confocal Microscopy

In this article, how cryo light microscopy and, in particular cryo confocal microscopy, is used to improve the reliability of cryo EM workflows is…

Mar 31, 2021

Whitepaper
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How FLIM Microscopy helps to detect microplastic pollution

The use of autofluorescence in biological samples is a widely used method to gain detailed knowledge about systems or organisms. This property is not…

Dec 28, 2020

Abstract
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A New World of Confocal Applications with the Next Generation White Light Lasers

As biological questions get more complex, there is an increasing need to study multiple events simultaneously in the same specimen. When preparing the…

Nov 19, 2020

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How to Quantify Label-free Blood Flow

The application note “Label-free Blood Flow Quantification” is a guide for data acquisition and analysis of blood flow using label-free third harmonic…

Sep 11, 2020

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How Can Immunofluorescence Aid Virology Research?

Modern virology research has become as crucial now as ever before due to the global COVID-19 pandemic. There are many powerful technologies and assays…

Sep 10, 2020

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Obtain maximum information from your specimen with LIGHTNING

LIGHTNING is an adaptive process for extraction of information that reveals fine structures and details, otherwise simply not visible, fully…

Aug 30, 2020

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Expanding the frontiers of confocal live cell imaging

To address the specific challenges of live cell confocal imaging and help researchers get closer to the truth, Leica Microsystems has re-imagined…

Aug 20, 2020

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Microscopy in Virology

The coronavirus SARS-CoV-2, causing the Covid-19 disease effects our world in all aspects. Research to find immunization and treatment methods, in…

Jul 13, 2020

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Explore Innovative Techniques to Separate Fluorophores with Overlapping Spectra

In this article we explore several strategies you can take to improve the separation of fluorophores and increase the number of fluorescent probes you…

May 05, 2020

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STELLARIS White light lasers

When it comes to choosing fluorescent probes for your multi-color experiments, you shouldn’t have to compromise. Now you can advance beyond…

Apr 28, 2020

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TauSense Technology Imaging Tools

Leica Microsystems’ TauSense technology is a set of imaging modes based on fluorescence lifetime. Found at the core of the STELLARIS confocal…

Apr 28, 2020

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The Power HyD detector family

Powerful photon counting detectors on the STELLARIS confocal platform provide improved photon counting, ultra-sensitive imaging and more color…

Apr 28, 2020

Story
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How to Uncover Hidden Dimensions in Research with Lifetime Imaging

Learn how fluorescence lifetime imaging adds information depth to your confocal experiments and reveals novel insights that are difficult or…

Apr 15, 2020

Whitepaper
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Learn how to Remove Autofluorescence from your Confocal Images

Autofluorescence can significantly reduce what you can see in a confocal experiment. This article explores causes of autofluorescence as well as…

Mar 23, 2020

Whitepaper