Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Latest Articles

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Investigating Axonal Pathfinding in the Accessory Olfactory System
Hernandez-Clavijo et. al. investigated the importance of TMEM16A, a calcium-activated chloride channel, for axonal pathfinding between the VNO and AOB…
Jun 27, 2022
Abstract
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Deciphering Signaling Pathways in Developmental Biology
This article shows how sharp, rapid imaging of neuronal progenitors in chick embryos with a THUNDER Imager Model Organism and small volume…
Feb 24, 2022
Case Study
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Accelerating Neuron Image Analysis with Automation
The ability to examine complex neural processes relies on the accurate reconstruction of neuronal networks at scale. Most data extraction methods in…
Nov 17, 2021
Webinar
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Designing your Research Study with Multiplexed IF Imaging
Multiplexed tissue analysis is a powerful technique that allows comparisons of cell-type locations and cell-type interactions within a single fixed…
Oct 28, 2021
Webinar
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Be Confident in your Results with Cell DIVE Validated Antibodies
The Cell DIVE System includes a carefully curated list of hundreds of commercially available antibodies validated to offer optimal specificity and…
Sep 29, 2021
Workflow
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Overcoming Multiplexed Imaging Roadblocks
Whether a single slide or a batch of slides processed on multiple Cell DIVE imagers, every step carried out by the Cell DIVE Acquisition Software…
Sep 29, 2021
Workflow
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Optimal Visualization in Brain Surgery
This case study “Treatment of the Galassi type III arachnoid cyst with the M530 OHX surgical microscope from Leica Microsystems” documents the…
Sep 22, 2021
Case Study
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Cortical Contributions to Complex Learning
This article describes the use of sharp, high contrast imaging to facilitate assessment of viral-construct placement in rat cortical brain tissue.…
Aug 17, 2021
Case Study
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Neuroscience Images
Neuroscience commonly uses microscopy to study the nervous system’s function and understand neurodegenerative diseases.
Jun 25, 2021
Gallery
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Coherent Raman Scattering Microscopy Publication List
CRS (Coherent Raman Scattering) microscopy is an umbrella term for label-free methods that image biological structures by exploiting the…
Jun 24, 2021
Story
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Fish and Chips Sheet into the Light
The zebrafish larval brain is small and contains about 1 million times less neurons than the human counterpart. The neural circuitry and the general…
May 05, 2021
Abstract
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Understanding Motor Sequence Generation Across Spatiotemporal Scales
We have developed a microscopy-based pipeline to characterize a developmentally critical behavior at the pupal stage of development, called the…
Apr 15, 2021
Webinar
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Investigating Synapses in Brain Slices with Enhanced Functional Electron Microscopy
A fundamental question of neuroscience is: what is the relationship between structural and functional properties of synapses? Over the last few…
Mar 08, 2021
Case Study
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How to improve your Biomarker Discovery Workflow with Laser Microdissection
Biomarkers can be used as indicators of certain diseases, such as cancer. The tumor microenvironment moved into the spotlight in this concern. It is…
Nov 16, 2020
Tutorial
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Neurosurgery with Heads-up Display
In the following video interviews Prof. Dr. Raphael Guzman, Vice Chairman of the Department of Neurosurgery at the University Hospital in Basel,…
Nov 11, 2020
Interview
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Studying Adipose Tissue Development and Expansion
This article discusses sharp, high-contrast imaging of whole mount adipose (fat) tissues specimens, which are thick and round (unsectioned), with a…
Aug 27, 2020
Case Study
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Study synaptic dynamics with millisecond precision in neurobiology
What if you could dissect the synaptic dynamics with millisecond precision? To resolve controversial questions in neurobiology employing new…
Aug 26, 2020
Story
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Evaluating Axon Regeneration After Brain or Spine Trauma of Mice
Damaged nerve regeneration was investigated using mouse spinal cord sections treated with compounds that counter axon growth inhibitor (AGI) proteins.…
Mar 17, 2020
Case Study