Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Latest Articles

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Workflows & Protocols: Connecting Microscopy and Molecular Biology in Neuroscience
The main topic during this course was how to apply laser microdissection in neuroscience. Leica specialists demonstrated why laser microdissection is…
Dec 04, 2015
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Switching Roles: The Functional Plasticity of Adult Tissue Stem Cells
Adult organisms have to adapt to survive, and the same is true for their tissues. Rates and types of cell production must be rapidly and reversibly…
May 18, 2015
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Super-resolution Imaging of the Natural Killer Cell Immunological Synapse on a Glass-supported Planar Lipid Bilayer
The glass-supported planar lipid bilayer system has been utilized in a variety of disciplines. One of the most useful applications of this technique…
Feb 12, 2015
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Axon Injury and Regeneration in the Adult Drosophila
Neural regeneration is a fascinating process with profound impact on human health, such that defining biological and genetic pathways is of interest.…
Jan 02, 2015
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Identification of Molecular Pathways Facilitating Glioma Cell Invasion In Situ
Gliomas are mostly incurable secondary to their diffuse infiltrative nature. Thus, specific therapeutic targeting of invasive glioma cells is an…
Dec 22, 2014
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Deeper Insights in Transparent Animals
CLARITY clearing derivatives for multiphoton microscopy. Transparent organisms help us to identify spatial arrangements and connections of cells and…
Nov 10, 2014
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A New Probe for Super-Resolution Imaging of Membranes Elucidates Trafficking Pathways
The molecular composition of the organelles involved in membrane recycling is difficult to establish as a result of the absence of suitable labeling…
Oct 17, 2014
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Correlated Optical and Isotopic Nanoscopy
The isotopic composition of different materials can be imaged by secondary ion mass spectrometry. In biology, this method is mainly used to study…
Aug 22, 2014
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Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing
Understanding the structure-function relationships at cellular, circuit, and organ-wide scale requires 3D anatomical and phenotypical maps, currently…
Aug 20, 2014
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STED Microscopy of Living Cells – New Frontiers in Membrane and Neurobiology
Recent developments in fluorescence far-field microscopy such as STED microscopy have accomplished observation of the living cell with a spatial…
Aug 12, 2014
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Abstracts of the 4th European Super-Resolution User-Club Meeting
The 4th Super-Resolution User Club Meeting was held in collaboration with Christian Eggeling and the Weatherall Institute of Molecular Medicine in…
Aug 08, 2014
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Interview with Dr. Yasushi Okada
Yasushi Okada, team leader at Riken Quantitative Biology Center in Osaka, Japan, investigates vesicular transport mechanisms in neuronal cells. As the…
Jun 03, 2014
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Capturing Cellular Dynamics with Millisecond Temporal Resolution
The combination of two powerful techniques: optogenetics and high-pressure freezing now makes it possible to visualize a dynamic cellular activity…
May 12, 2014
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Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation
In mice, the ability to detect pheromones is principally mediated by the vomeronasal organ (VNO). Here, an acute tissue slice preparation of VNO for…
May 02, 2014
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The Morbus Parkinson Puzzle
A characteristic sign of M. Parkinson is the deterioration of dopaminergic neurons in the mid-brain, specifically in the substantia nigra (SN, black…
Mar 27, 2014
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Optogenetic Toolkit Goes Multicolor
Optogenetics is a technique that allows scientists to control neurons’ electrical activity with light by engineering them to express light-sensitive…
Feb 25, 2014
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Production of RNA for Transcriptomic Analysis from Mouse Spinal Cord Motor Neuron Cell Bodies by Laser Capture Microdissection
High-quality total RNA has been prepared from cell bodies of mouse spinal cord motor neurons by laser capture microdissection after staining spinal…
Jan 30, 2014
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Euro-BioImaging – the pan-European Open Access Research Infrastructure Project for Biological and Medical Imaging Technologies
Euro‐BioImaging is a large‐scale pan‐European research infrastructure project on the European Strategy Forum on Research Infrastructures (ESFRI)…
Nov 13, 2013
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