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Super-Resolution Optical Microscopy of Lipid Plasma Membrane Dynamics
Plasma membrane dynamics are an important ruler of cellular activity, particularly through the interaction and diffusion dynamics of membrane-embedded…
Dec 23, 2016Abstract -
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Abstracts of the 6th European Super-Resolution User-Club Meeting
The 6th European Super-Resolution User Club Meeting was held in collaboration with Dr. Timo Zimmermann, CRG, and Dr. Pablo Loza-Alvarez, ICFO,…
Oct 18, 2016Story -
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Mirror-Enhanced Super-Resolution Microscopy
Axial excitation confinement beyond the diffraction limit is crucial to the development of next-generation, super-resolution microscopy. STimulated…
Aug 18, 2016Abstract -
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The Actin Cytoskeleton Modulates the Activation of iNKT Cells by Segregating CD1d Nanoclusters on Antigen-Presenting Cells
The ability of invariant natural killer T (iNKT) cells to recognize endogenous antigens represents a distinct immune recognition strategy, which…
Aug 10, 2016Abstract -
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Translation Microscopy (TRAM) for Super-Resolution Imaging
Super-resolution microscopy is transforming our understanding of biology but accessibility is limited by its technical complexity, high costs and the…
Jul 22, 2016Abstract -
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Two-Photon Excitation STED Microscopy with Time-Gated Detection
We report on a novel two-photon excitation stimulated emission depletion (2PE-STED) microscope based on time-gated detection. The time-gated detection…
Jun 21, 2016Abstract -
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Super-Resolution Mapping of Neuronal Circuitry With an Index-Optimized Clearing Agent
Super-resolution imaging deep inside tissues has been challenging, as it is extremely sensitive to light scattering and spherical aberrations. Here,…
Apr 27, 2016Abstract -
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How to Combine STED and CLARITY
Previously, the preferred way to study the subtlest elements of the kidney, such as foot processes and the slit diaphragm has been by the use of…
Jan 29, 2016Abstract -
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Video: Fluorescence is a State of Mind
How to break a fundamental law of physics and win a Nobel Prize to boot. Stefan Hell explains super-resolved fluorescence microscopy for which he…
Jan 07, 2016Story -
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Super-Resolution Microscopy of the Synaptic Active Zone
At the presynaptic active zone (AZ) a variety of specialized proteins are assembled to complex architectures, which set the basis for speed, precision…
Dec 15, 2015Abstract -
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Probes that FIT RNA
We have been developing new tools based on fluorogenic forced intercalation (FIT) probes for RNA detection quantification and interference in…
Sep 22, 2015Story -
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STED Nanoscopy with Fluorescent Quantum Dots
The widely popular class of quantum-dot molecular labels could so far not be utilized as standard fluorescent probes in STED (stimulated emission…
Aug 13, 2015Abstract -
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A Straightforward Approach for Gated STED-FCS to Investigate Lipid Membrane Dynamics
Recent years have seen the development of multiple technologies to investigate, with great spatial and temporal resolution, the dynamics of lipids in…
Aug 03, 2015Abstract -
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A Lipid Bound Actin Meshwork Organizes Liquid Phase Separation in Model Membranes
The eukaryotic cell membrane is connected to a dense actin rich cortex. We present FCS and STED experiments showing that dense membrane bound actin…
Jul 15, 2015Abstract -
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Abstracts of the 5th European Super-Resolution User-Club Meeting
The 5th Super-Resolution User Club Meeting was held in collaboration with Professor Kees Jalink and The Netherlands Cancer Institute (NKI) in…
Jun 23, 2015Story -
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Encoding and Decoding Spatio-Temporal Information for Super-Resolution Microscopy
The challenge of increasing the spatial resolution of an optical microscope beyond the diffraction limit can be reduced to a spectroscopy task by…
Apr 17, 2015Abstract -
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STED Nanoscopy: A Glimpse into the Future
The well-known saying of "Seeing is believing" became even more apt in biology when stimulated emission depletion (STED) nanoscopy was introduced in…
Mar 23, 2015Abstract -
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Pathways to Optical STED Microscopy
STED nanoscopy has evolved to a highly versatile tool for the observation of the living cell, more and more finding its way into state-of-the-art…
Mar 12, 2015Abstract