Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Latest Articles

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A novel concept in fluorescence lifetime imaging enabling video-rate confocal FLIM
SP8 FALCON (FAst Lifetime CONtrast) is a fast and completely integrated fluorescence lifetime imaging microscopy (FLIM) confocal platform. SP8 FALCON…
Oct 17, 2019
Abstract
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Multiphoton imaging bolsters findings on in vitro differentiation of pluripotent stem cell-derived podocyte
The renal corpuscle of the kidney comprises a glomerular vasculature embraced by podocytes and supported by mesangial myofibroblasts. Their combined…
Aug 26, 2019
Abstract
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Improved tree-ring visualization using autofluorescence
Autofluorescence can be a very practical tool for the visualization of growth rings in wood, especially when these structures are hard to distinguish,…
Jul 23, 2019
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Single-residue bioorthogonal labeling of G protein-coupled receptors (GPCRs) in live cells for quantitative analysis
To perform quantitative studies of membrane bound G protein-coupled receptors (GPCRs) with high-performance microscopy, the proteins must first be…
Jun 26, 2019
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Bridging Structure and Dynamics at the Nanoscale through Optogenetics and Electrical Stimulation
Nanoscale ultrastructural information is typically obtained by means of static imaging of a fixed and processed specimen. However, this is only a…
May 20, 2019
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Surgeons describe how Proveo 8 helps to streamline their workflow
Experienced ophthalmic surgeons explain how they perform cataract surgery with high efficiency using the Proveo 8 ophthalmic microscope from Leica…
May 02, 2019
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Analysis of Tissue Sections Assisted by Fluorescence Laser Microdissection
Lectin microarray (LMA) is a highly sensitive technology used to obtain the global glycomic profiles of endogenous glycoproteins in biological samples…
Mar 26, 2019
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Use of EnFocus Intraoperative OCT to overcome difficulties in visualization during Synechiolysis
The aim of this study was to describe intraoperative optical coherence tomography (OCT) as an adjunctive device for peripheral synechiolysis in a…
Mar 17, 2019
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How to Develop an Airway Epithelial Cell Model
The present study describes the optimal growth conditions for the proliferation and differentiation of bovine bronchial epithelial cells (BBECs). The…
Mar 06, 2019
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Researchers use Functional Imaging to Elucidate the Role of Cellular Zn²⁺ in Human Immunity
An international consortium of researchers has found a new mutation in a gene harboring a reticulum-to-cytoplasm zinc transporter. The gene is called…
Feb 27, 2019
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Simultaneously Measuring Image Features and Resolution in Live-Cell STED Images
Reliable interpretation and quantification of cellular features in fluorescence microscopy requires an accurate estimate of microscope resolution.…
Nov 12, 2018
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MONENSIN SENSITIVITY1 (MON1)/CALCIUM CAFFEINE ZINC SENSITIVITY1 (CCZ1)
Programmed cell death (PCD)-triggered degradation of plant tapetum is essential for microspore development and pollen coat formation; however, little…
Oct 22, 2018
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Nanodroplet Processing Platform for Deep and Quantitative Proteome Proﬁling of 10–100 Mammalian Cells
Nanoscale or single-cell technologies are critical for biomedical applications. However, current mass spectrometry (MS)-based proteomic approaches…
Sep 12, 2018
Abstract
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Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector
Bloodsucking insects play a major role in the transmission of pathogens that cause major tropical diseases. Their capacity to transmit these diseases…
Jul 29, 2018
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Researchers Find a “Digital” Mechanism Behind Neuronal Changes from Learning
Neurons react to learning and memory by activating synaptic connections. The mechanisms behind this fundamental process are complex and poorly…
Jun 04, 2018
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mTORC1 Promotes Proliferation of Immature Schwann Cells and Myelin Growth of Differentiated Schwann Cells
The myelination of axons is essential for neuronal wiring and normal nervous system functions. In the peripheral nervous system, Schwann cells (SCs)…
May 16, 2018
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High-Resolution 3D Imaging of Whole Organ after Clearing
Zebrafish testis has become a powerful model for reproductive biology of teleostean fishes and other vertebrates and encompasses multiple applications…
May 08, 2018
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Leica is MAD about LIBS
When analyzing material for cleanliness testing, users normally just want a simple way to know whether the particle under scrutiny is normal debris or…
Apr 22, 2018
Abstract