Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Latest Articles

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Color Infidelity: Why Using a Light Source Incorrectly is Cheating on your Data
There are many influences on color in the imaging process including lighting, optics, sensor, and monitor, and ultimately print. The first, and…
Nov 19, 2015
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The Value of Intraoperative OCT Imaging in Vitreoretinal Surgery
The role of iOCT in vitreoretinal surgery continues to be defined by active research and enhancements to integrative technologies. Further research is…
Nov 09, 2015
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Handheld Optical Coherence Tomography During Sedation in Young Children With Optic Pathway Gliomas
Monitoring young children with optic pathway gliomas (OPGs) for visual deterioration can be difficult owing to age-related noncompliance. Optical…
Nov 09, 2015
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What do you Call a Drosophila who Likes to Drink? A Bar Fly!
The thought of a Drosophoila headed to the local bar for a drink creates a funny joke, but after long hours of sorting flies under a microscope that…
Oct 21, 2015
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New Predatory Cockroaches (Insecta: Blattaria: Manipulatoridae fam.n.) from the Upper Cretaceous Myanmar Amber
We describe a new extinct lineage Manipulatoridae (new family) of cockroaches from the Upper Cretaceous (Cenomanian) amber of Myanmar. Manipulator…
Oct 14, 2015
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Light Sheet Microscopy Turned Vertically
Living cells and organisms often suffer from the high light intensities used for fluorescent imaging. Light sheet microscopy reduces phototoxic…
Oct 02, 2015
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Fluorescent Proteins Illuminate Cell Biology
Green fluorescent protein (GFP) isolated from the jellyfish Aequorea victoria and GFP-like fluorescent proteins from other animals have had an…
Sep 18, 2015
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Co-Orientation: Quantifying Simultaneous Co-Localization and Orientational Alignment of Filaments in Light Microscopy
Co-localization analysis is a widely used tool to seek evidence for functional interactions between molecules in different color channels in…
Sep 16, 2015
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Progressive Glucose Stimulation of Islet Beta Cells Reveals a Transition From Segregated to Integrated Modular Functional Connectivity Patterns
Collective beta cell activity in islets of Langerhans is critical for the supply of insulin within an organism. In order to get a detailed insight…
Sep 03, 2015
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STED Nanoscopy with Fluorescent Quantum Dots
The widely popular class of quantum-dot molecular labels could so far not be utilized as standard fluorescent probes in STED (stimulated emission…
Aug 13, 2015
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A Straightforward Approach for Gated STED-FCS to Investigate Lipid Membrane Dynamics
Recent years have seen the development of multiple technologies to investigate, with great spatial and temporal resolution, the dynamics of lipids in…
Aug 03, 2015
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Cortical Actin Networks Induce Spatio-temporal Confinement of Phospholipids in the Plasma Membrane – A Minimally Invasive Investigation by STED-FCS
Important discoveries in the last decades have changed our view of the plasma membrane organisation. Specifically, the cortical cytoskeleton has…
Jul 24, 2015
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A Lipid Bound Actin Meshwork Organizes Liquid Phase Separation in Model Membranes
The eukaryotic cell membrane is connected to a dense actin rich cortex. We present FCS and STED experiments showing that dense membrane bound actin…
Jul 15, 2015
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Transmission Electron Microscopy Sample Preparation Protocols for the Ultrastructural Study of Cysts of Free-living Protozoa
Cysts of free-living protozoa have an impact on the ecology and epidemiology of bacteria because they may act as a transmission vector or shelter the…
Jul 02, 2015
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iMSRC: Converting a Standard Automated Microscope into an Intelligent Screening Platform
Microscopy in the context of biomedical research is demanding new tools to automatically detect and capture objects of interest. The few extant…
Jun 22, 2015
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Correlative In-Resin Super-Resolution and Electron Microscopy Using Standard Fluorescent Proteins
We introduce a method for correlative in-resin super-resolution fluorescence and electron microscopy (EM) of biological structures in mammalian…
Jun 04, 2015
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Correlative Light and Electron Microscopy – Get Your Free CLEM e-Book for Download
The urge to go deeper into the microscopic world has led researchers to combine the versatility of the light microscopy (LM) with the resolution power…
May 28, 2015
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Switching Roles: The Functional Plasticity of Adult Tissue Stem Cells
Adult organisms have to adapt to survive, and the same is true for their tissues. Rates and types of cell production must be rapidly and reversibly…
May 18, 2015
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