Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!

Latest Articles

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Investigating Axonal Pathfinding in the Accessory Olfactory System
Hernandez-Clavijo et. al. investigated the importance of TMEM16A, a calcium-activated chloride channel, for axonal pathfinding between the VNO and AOB…
Jun 30, 2022
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Tumor MHC Expression and Intralesional IL2 Response in Melanoma
Genomics profiling and Cell DIVE multiplex imaging allows researchers to understand the immune cell phenotypes that most strongly predict response to…
May 19, 2022
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Wt1 Genes Can Induce a Cardiomyocyte to Epicardial-like Cell Fate Transition
From this study, it was concluded that Wt1 plays a yet undescribed role for cardiomyocyte differentiation by repressing chromatin opening at specific…
Apr 27, 2022
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Multicellular Organization during Stem Cell Dynamics
Multicellular organization, e.g. during tissue morphogenesis or of human embryonic stem cells, relies on collective cytoskeletal dynamics. During…
Feb 21, 2022
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Phosphoprotein Regulates Integrin Endosomal Trafficking
Integrins are involved in cell-cell and cell-extracellular matrix adhesion. In addition, they mediate several signaling pathways, regulating e.g. cell…
Feb 21, 2022
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Structural HIV-1 Env Trimers Dynamics on Living T Cells
In this article, we focus on the molecular mechanism of the Env protein as it interacts with T cell, the primary target of HIV-1 [Carlon-Andres I et…
Feb 09, 2022
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A Versatile Palette of Fluorescent Probes
Researchers at the Max Planck Institute for Medical Research in Heidelberg have developed a general strategy to synthesize live-cell compatible…
Jan 24, 2022
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Mapping 4D cell models with VR
Plant researchers Takumi Higaki and Hidenobu Mizuno have developed a framework to map leaf pavement cells in 4D using AI software with VR equipment.
Dec 08, 2021
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STELLARIS Contributes to Understanding COVID-19 Infection
What are the structural and functional consequences of a SARS-CoV-2 infection? To answer this important question, the authors used 3D cultures that…
Nov 11, 2021
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Brain-Tumor-Microenvironment Study in Motion
In the present study, we show, in an in vivo longitudinal study, that the Slit-Robo pathway is critical for immunosuppressive myeloid cell…
Oct 26, 2021
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STED sheds insight on mitochondrial protein synthesis
In this paper the authors have adapted a click chemistry-based method coupled with stimulated emission depletion nanoscopy (STED) to address these…
Oct 25, 2021
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Mitochondrial dynamics quantitatively revealed by STED nanoscopy
Mitochondria are vital subcellular organelles, which can generate energy to support the entire lifecycle of biological cells. However, conventional…
Oct 25, 2021
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Spectroscopic Evaluation of Red Blood Cells
Hemoglobinopathies are a major healthcare problem. This study presents a possible diagnostic tool for thalassemia which is based on confocal…
Aug 30, 2021
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Visualization of Submitochondrial Protein Distributions
By allowing visualization of submitochondrial protein distributions, fluorescence nanoscopy offers significant advantages for understanding cell death…
Aug 16, 2021
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DNA Replication in Cancer Cells
DNA synthesis can be impeded by collisions between the DNA replication machinery and co-transcriptional R-loops leading to a major source of genomic…
Jul 27, 2021
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Phasor FLIM Detects Metabolic Differences
The maintenance of normal blood glucose levels is defective in diabetes caused by dysfunction of the alpha and beta cells in islets. To understand…
Jun 28, 2021
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Following Ca²⁺ Changes in Acutely Stimulated Spheroids
Spheroids are easy and cost-effective 3D cell cultures, useful for fundamental and applied research. They can bridge the gap between 2D and in vivo…
Jun 23, 2021
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Analyzing Structural and Functional Testicular Anatomy
Fleck, Kenzler et al. have shown that, in mice, muscle-like cells are located within the walls of seminiferous tubules. Using CLARITY and a Leica…
Jun 23, 2021
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