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Science Lab

Science Lab

Science Lab

The knowledge portal of Leica Microsystems offers scientific research and teaching material on the subjects of microscopy. The content is designed to support beginners, experienced practitioners and scientists alike in their everyday work and experiments. Explore interactive tutorials and application notes, discover the basics of microscopy as well as high-end technologies – become part of the Science Lab community and share your expertise!
Depth coding of endothelial cells in zebrafish eye. Courtesy of Basile Gurchenkov, Imaging Center of the IGBMC, Illkirch-Graffenstaden, France.

Gentle and Flexible 3D Imaging of Biological and Cleared Samples

For 3D imaging of biological samples, light sheet microscopy is a powerful and sensitive tool allowing you to measure (sub)cellular dynamics over long periods of time. Meanwhile, confocal microscopy,…
Dr. Blanc using the M320 dental microscope with ultra-low binoculars

Improving Ergonomics With a Dental Microscope

Here, we show you how Dr. David Blanc, a dental surgeon and ergonomics consultant, improves physical comfort using a dental microscope with ultra-low binoculars. Through optimized ergonomics, Dr.…
Identification of distinct structures_roundworm_Ascaris_female

Find Relevant Specimen Details from Overviews

Switch from searching image by image to seeing the full overview of samples quickly and identifying the important specimen details instantly with confocal microscopy. Use that knowledge to set up…
Multi-color SRS image of a tri-cellular cancer spheroid

The Potential of Coherent Raman Scattering Microscopy at a Glance

Coherent Raman scattering microscopy (CRS) is a powerful approach for label-free, chemically specific imaging. It is based on the characteristic intrinsic vibrational contrast of molecules in the…
U2OS cells labelled with SiR Actin, TMRE, CellEvent™, and DAPI; 13-hour time-lapse imaging; apoptosis-inducer staurosporine

Simplifying Complex Fluorescence Multiwell Plate Assays

Apoptosis, or programmed cell death, occurs during organism embryo development to eliminate unwanted cells and during healing in adults to rid the body of damaged cells and help prevent cancer.…
Formation of 3D spheroids; Time lapse acquisition over 72 hours

Efficient Long-term Time-lapse Microscopy

When doing time-lapse microscopy experiments with spheroids, there are certain challenges which can arise. As the experiments can last for several days, prolonged sample survival must be achieved…
Laboratory

Factors for Selecting Clinical Microscopes

If you are considering the purchase of new clinical microscopes for yourself or your team, you will think about many options, vendors, and microscope models. Here are some tips to help you come to the…
Histopathological sample, 40x magnification

Clinical Microscopy: Considerations on Camera Selection

The need for images in pathology laboratories has significantly increased over the past few years, be it in histopathology, cytology, hematology, clinical microbiology, or other applications. They…
Operating room, PROVIDO

Free Flap Procedures in Oncological Reconstructive Surgery

Free flap surgery is considered the gold standard for breast, head and neck reconstructions for cancer patients. These procedures, which enable functional and aesthetic rehabilitation, can be quite…
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