Leica Science Lab - Tag : History https://www.leica-microsystems.com//science-lab/tag/history/ Article tagged with History en-US https://www.leica-microsystems.com/19260 Basics in Microscopy Fluorescence Microscopy Milestones in Incident Light Fluorescence Microscopy Since the middle of the last century, fluorescence microscopy developed into a bio scientific tool with one of the biggest impacts on our understanding of life. Watching cells and proteins with the help of fluorescence molecules is a standard method in nearly every life science discipline today. This broad application range goes back to the technical work of some researchers who wanted to improve and simplify fluorescence microscopic labor. One person who was involved in that development was the Dutch medic Johann Sebastiaan Ploem. https://www.leica-microsystems.com/science-lab/milestones-in-incident-light-fluorescence-microscopy/ Mon, 06 Mar 2017 08:39:00 +0000 Dr. Christoph Greb https://www.leica-microsystems.com/13935 Fluorescence Microscopy Video Talk by Roger Tsien: Fluorescent Proteins Live cell imaging has been revolutionized by the discovery of the green fluorescent protein (GFP). This lecture covers the history of GFP, how it folds and becomes fluorescent, how it has been mutated to produce additional colors (blue, cyan, yellow), and the discovery of red fluorescent proteins from corals. It also covers novel photoswitchable and photoactivatible fluorescent proteins, whose color can be changed by light, and new infrared fluorescent proteins. https://www.leica-microsystems.com/science-lab/video-talk-by-roger-tsien-fluorescent-proteins/ Wed, 07 Oct 2015 16:55:00 +0000 PhD Roger Y. Tsien https://www.leica-microsystems.com/16124 Basics in Microscopy A Brief History of Light Microscopy – From the Medieval Reading Stone to Super-Resolution The history of microscopy begins in the Middle Ages. As far back as the 11th century, plano-convex lenses made of polished beryl were used in the Arab world as reading stones to magnify manuscripts. However, the further development of these lenses into the first microscopes cannot be attributed to any one person. It took the ideas and designs of many scientists and scholars to produce instruments capable of strong magnification. https://www.leica-microsystems.com/science-lab/a-brief-history-of-light-microscopy-from-the-medieval-reading-stone-to-super-resolution/ Tue, 08 Sep 2015 17:41:00 +0000 Wymke Ockenga https://www.leica-microsystems.com/14400 Basics in Microscopy Video Talk by Joseph Gall: Early History of Microscopy Joseph Gall takes us through the history of early microscopes and the discovery of the cell. Compound microscopes were invented alongside the telescope in the 17th century; however these microscopes were not widely used until the late 19th century due to optical aberrations. In the meantime, simple microscopes were used throughout the 1700s and 1800s to make major discoveries in biology, including the first descriptions of the nucleus, cilia, cells, bacteria, and protozoans. Once optics improved in the mid to late 1800s, compound microscopes were used to discover chromosomes, mitosis, and other cellular structures. https://www.leica-microsystems.com/science-lab/video-talk-by-joseph-gall-early-history-of-microscopy/ Tue, 11 Aug 2015 07:48:00 +0000 BS, PhD Joseph Gall https://www.leica-microsystems.com/9512 Basics in Microscopy Videos on the Leica History (German only) April 26th 2013 is the 170th anniversary of the birth of Ernst Leitz I (1843-1920), who turned a small optical workshop in Wetzlar into an optics company of world renown. At the beginning of the 20th century, the Ernst Leitz Optical Works rapidly became one of the leading suppliers of microscopes and optical products. This history is illuminated by the two films presented here. https://www.leica-microsystems.com/science-lab/videos-on-the-leica-history-german-only/ Wed, 10 Apr 2013 20:21:00 +0000 https://www.leica-microsystems.com/7797 Basics in Microscopy Stereo Microscopy Widefield Microscopy 50 Years of Image Analysis Modern image analysis systems perform highly sophisticated image processing functions on images from an automated microscope and digital camera. 50 years ago, the first image analysis system was analogue, based on a video camera and the area measurements could be read from a meter. Nevertheless, it marked the beginning of automation in this field. https://www.leica-microsystems.com/science-lab/50-years-of-image-analysis/ Sun, 18 Nov 2012 23:00:00 +0000 Geoff Jenkinson https://www.leica-microsystems.com/5256 Fluorescence Microscopy Fluorescent Proteins - From the Beginnings to the Nobel Prize Fluorescent proteins are the fundament of recent fluorescence microscopy and its modern applications. Their discovery and consequent development was one of the most exciting innovations for life sciences in the last century and the starting point of the deciphering of numberless natural phenomena. https://www.leica-microsystems.com/science-lab/fluorescent-proteins-from-the-beginnings-to-the-nobel-prize/ Thu, 16 Feb 2012 23:00:00 +0000 Dr. Christoph Greb https://www.leica-microsystems.com/9478 Surgical Microscopy Wilhelm Fabry – Surgeon, Inventor, and Publicist Before academic education for medical practitioners became the norm, barber-surgeons treated wounds and performed minor operations as members of the tradesmen’s guild as late as the end of the 16th century. The surgeon Wilhelm Fabry, born in Hilden in 1560, Germany, was not content with this classification of his profession, however. https://www.leica-microsystems.com/science-lab/wilhelm-fabry-surgeon-inventor-and-publicist/ Fri, 13 Aug 2010 19:06:00 +0000 M. A. Janika Wiesner, Dr. Wolfgang Antweiler https://www.leica-microsystems.com/5139 Stereo Microscopy The History of Stereo Microscopy – Part III Until the middle of the 19th century, microscopes were hand-crafted custom instruments. At the time, it was not possible to predict the properties of a lens in advance, so lenses were shaped and tested repeatedly until they delivered the desired magnification. https://www.leica-microsystems.com/science-lab/the-history-of-stereo-microscopy-part-iii/ Thu, 11 Jan 2007 13:03:00 +0000 Daniel Goeggel https://www.leica-microsystems.com/5137 Stereo Microscopy The History of Stereo Microscopy – Part II For millennia, glass was admired for its beauty and the artful objects that could be created with it. With the rise of the exact sciences, however, researchers became more demanding with regard to glass quality. Traditional glass was not suitable for microscope lenses – streaks, bubbles and inclusions containing impurities made precise observation impossible. https://www.leica-microsystems.com/science-lab/the-history-of-stereo-microscopy-part-ii/ Thu, 11 Jan 2007 10:18:00 +0000 Daniel Goeggel https://www.leica-microsystems.com/5129 Stereo Microscopy The History of Stereo Microscopy – Part I The 17th century in Europe was marked by the Thirty Years' War (1618–1648). The population lived in constant fear and poverty. Marauding hordes wandered the countryside; failed harvests, plagues, pestilence and starvation were the order of the day. Most of the population had little in the way of clothing or shoes, and lived in modest huts infested by parasites and rats. https://www.leica-microsystems.com/science-lab/the-history-of-stereo-microscopy-part-i/ Wed, 10 Jan 2007 23:00:00 +0000 Daniel Goeggel https://www.leica-microsystems.com/9682 Fluorescence Microscopy Multi-Wavelength Epi-Illumination in Fluorescence Microscopy Fluorescence is a process where a substance after having absorbed light (photons) emitts a radiation the wavelength (colour) of which is longer than that of the absorbed light, and where this emission stops immediately after cessation of the excitation. This phenomenon is the basic element of fluorescence microscopy and its application. https://www.leica-microsystems.com/science-lab/multi-wavelength-epi-illumination-in-fluorescence-microscopy/ Sat, 01 Dec 2001 15:35:00 +0000 Professor em. Johan Sebastiaan Ploem, Dr. Friedrich Walter