Leica Science Lab - Tag : Cancer Research https://www.leica-microsystems.com//science-lab/tag/tags/cancer-research-1/show/Tag/ Article tagged with Cancer Research en-US https://www.leica-microsystems.com/24929 Confocal Microscopy Visualize mechanical interactions of Cancer Cells Cells interact with their environment. Not only on the base of chemical signals, but also by sensing and modifying mechanical properties of the extracellular matrix. The research goal of Dr. Bo Sun’s group at Oregon State University is to understand such interactions. One of their tools is visualization of matrix properties with a TCS SPE confocal microscope. https://www.leica-microsystems.com//science-lab/visualize-mechanical-interactions-of-cancer-cells/ Tue, 16 Apr 2019 22:00:00 +0000 Dr. Rolf T. Borlinghaus https://www.leica-microsystems.com/20306 Super-Resolution STED Nanoscopy at the forefront of cancer research Alison Dun is the postdoctoral facility manager for the Edinburgh Super-Resolution Imaging Consortium (ESRIC), Heriot-Watt University, Edinburgh, UK. She has used a large range of microscope techniques during her PhD work. In a video published by BBC News, Alison Dun explains how STED (stimulated emission depletion) microscopes help researchers in the fight against cancer by getting a better understanding of the processes that go wrong in the human body, thus giving hope for future treatments. https://www.leica-microsystems.com//science-lab/sted-nanoscopy-at-the-forefront-of-cancer-research/ Thu, 05 Jul 2018 22:00:00 +0000 PhD Alison Dun, Dr. Julia Roberti https://www.leica-microsystems.com/19451 Live-Cell Imaging Fluorescence Microscopy Multiphoton Microscopy Five Questions Asked: Prof. Dr. Jacco van Rheenen speaks about the most important considerations when imaging deep into mouse tissue When operating a confocal microscope, or when discussing features and parameters of such a device, we inescapably mention the pinhole and its diameter. This short introductory document is meant to explain the significance of the pinhole for those, who did not want to spend too much time to dig into theory and details of confocal microscopy but wanted to have an idea about the effect of the pinhole. https://www.leica-microsystems.com//science-lab/five-questions-asked-prof-dr-jacco-van-rheenen-speaks-about-the-most-important-considerations-when-imaging-deep-into-mouse-tissue/ Fri, 19 May 2017 05:47:00 +0000 PhD Jacco van Rheenen, Dr. Bernd Sägmüller https://www.leica-microsystems.com/17939 Laser Microdissection Workflows & Protocols: Laser Microdissection for Pathology and Cancer Research Tumor development results from mutations in our DNA. For their deeper analysis, cancer researchers have to dissect the relevant tissue areas. Here we report the reason why laser microdissection is a perfect tool for this purpose and how this was taught in the course of a workshop held in Brazil. With the Leica LMD system pure tumor material can be selected and dissected for downstream analysis to ensure 100% pure starting material without any risk of cross contamination with healthy cells. https://www.leica-microsystems.com//science-lab/workflows-protocols-laser-microdissection-for-pathology-and-cancer-research/ Wed, 04 May 2016 11:30:00 +0000 Dr. Falk Schlaudraff, Dr. Christoph Greb https://www.leica-microsystems.com/17437 Fluorescence Microscopy Stereo Microscopy Investigating the Influence of Hormone Signaling Pathways on Mammary Gland Development and the Onset of Breast Cancer Over their entire lifetime, 1 out of 8 women can suffer from breast cancer. The risk of developing breast cancer (mammary carcinogenesis) increases with a woman’s age and is related to her reproductive history. The chance of mammary carcinogenesis is less for women who give birth to a child before the age of 30. However, it is now known that the risk of breast cancer also can depend on the number of times a woman experiences elevated blood serum progesterone levels, in relation to the menstrual cycle, before her first pregnancy. https://www.leica-microsystems.com//science-lab/investigating-the-influence-of-hormone-signaling-pathways-on-mammary-gland-development-and-the-onset-of-breast-cancer/ Thu, 21 Jan 2016 11:12:00 +0000 MD Cathrin Brisken, PhD Renuga Devi Rajaram, PhD Duje Buric, MSc Ayyakkannu Ayyanan, PhD James DeRose https://www.leica-microsystems.com/14920 Multiphoton Microscopy CLEM Live-Cell Imaging Correlating Intravital Multi-Photon Microscopy to 3D Electron Microscopy of Invading Tumor Cells Using Anatomical Reference Points Cancer research unsing multiphoton microscopy and 3D electron microscopy. Correlative microscopy combines the advantages of both light and electron microscopy to enable imaging of rare and transient events at high resolution. Performing correlative microscopy in complex and bulky samples such as an entire living organism is a time-consuming and error-prone task. https://www.leica-microsystems.com//science-lab/correlating-intravital-multi-photon-microscopy-to-3d-electron-microscopy-of-invading-tumor-cells-using-anatomical-reference-points/ Fri, 24 Apr 2015 13:06:00 +0000 https://www.leica-microsystems.com/15113 Live-Cell Imaging Fluorescence Microscopy Immunotherapy to Combat Cancer: "Sleeping Beauty" – DNA Plasmid-based Gene Transfer System to Modify T Cells Fighting cancer is a major goal of present-day medicine. So far mainly surgery, chemotherapy or radiation therapy are utilized to extinguish cancerous tissue, or at least set limits to it. Interestingly the human immune system has effective potential to fight cancer cells. Typically it reacts on parasitic, viral or bacterial infections. Thereby T-cells help to destroy infested cells after binding them via their specific antigen receptor. https://www.leica-microsystems.com//science-lab/immunotherapy-to-combat-cancer-sleeping-beauty-dna-plasmid-based-gene-transfer-system-to-modify-t-cells/ Wed, 28 Jan 2015 19:55:00 +0000 Dr. Christoph Greb https://www.leica-microsystems.com/13879 Super-Resolution Video Interviews with Kees Jalink Kees Jalink's group at the Netherlands Cancer Institute in Amsterdam, The Netherlands, explores signal transduction pathways and cell adhesion processes in cancer cells. In his eyes especially the new three-dimensional nanoscopic view of the relevant structure of interest is an essential feature to get the full picture. https://www.leica-microsystems.com//science-lab/video-interviews-with-kees-jalink/ Fri, 29 Aug 2014 11:58:00 +0000 PhD Kees Jalink, MSc Leila Nahidiazar, Dipl. oec.-troph. Anja Schué, Dr. Christoph Greb https://www.leica-microsystems.com/2561 Multiphoton Microscopy Live-Cell Imaging Confocal Microscopy Stem Cell Biology in Cancer Research The comprehension of stem cell biology and its molecular basis is now acquiring paramount importance in cancer research. The need to look at a single, possibly living, cell makes fluorescence microscopy and confocal microscopy invaluable allies in the study of stem cells. https://www.leica-microsystems.com//science-lab/stem-cell-biology-in-cancer-research/ Thu, 22 Apr 2010 22:00:00 +0000 Laura Furia, Angelo Cicalese, Ilaria Rancati, Isabella Ponzanelli, Paolo Bianchini, Prof. Alberto Diaspro, Mario Faretta