Leica Science Lab - Tag : Mitochondria https://www.leica-microsystems.com//science-lab/tag/tags/mitochondria/show/Tag/ Article tagged with Mitochondria en-US https://www.leica-microsystems.com/20350 Widefield Microscopy Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector Bloodsucking insects play a major role in the transmission of pathogens that cause major tropical diseases. Their capacity to transmit these diseases is directly associated with the availability and turnover of energy sources. Proline is the main readily-mobilizable fuel of the tsetse fly, which is the vector of sub-species of Trypanosoma brucei parasites that cause human sleeping sickness and are partly responsible for animal trypanosomiasis (Nagana disease) in sub-Saharan Africa. https://www.leica-microsystems.com//science-lab/proline-metabolism-is-essential-for-trypanosoma-brucei-brucei-survival-in-the-tsetse-vector/ Sun, 29 Jul 2018 22:00:00 +0000 https://www.leica-microsystems.com/16565 Super-Resolution Cross-strand Binding of TFAM to a Single mtDNA Molecule Forms the Mitochondrial Nucleoid Scientists from three Max Planck Institutes have gained fundamental insights into the organization of mitochondrial DNA (mtDNA). The researchers observed in high-resolution images gained with nobel prize-winning microscopy techniques that single copies of mtDNA are packaged by a specialized protein into slightly elongated structures of circa 100 nm in length. https://www.leica-microsystems.com//science-lab/cross-strand-binding-of-tfam-to-a-single-mtdna-molecule-forms-the-mitochondrial-nucleoid/ Tue, 17 Nov 2015 17:20:00 +0000 Dr. Christian Kukat https://www.leica-microsystems.com/7903 Super-Resolution Mitochondrial DNA Molecules are Packaged Individually At the Max Planck Institute for Biology of Ageing in Cologne founded in 2008, three departments are working on the molecular, physiological and evolutionary mechanisms of the ageing of cells, tissue and organisms. The long-term aim of the research is to help people age more healthily. Here, Dr. Christian Kukat from the department of Professor Nils-Göran Larsson is examining the role played by mitochondria in the ageing process. In close collaboration with Dr. Christian Wurm from the research group of Professor Stefan Jakobs at the Max Planck Institute for Biophysical Chemistry in Göttingen and researchers at the University of Gothenburg, Sweden, they harnessed super-resolution STED microscopy to find out new and surprising facts about the mitochondrial nucleoid. https://www.leica-microsystems.com//science-lab/mitochondrial-dna-molecules-are-packaged-individually/ Sun, 06 Jan 2013 23:00:00 +0000 Dr. Matthias Schauen, Dr. Christian Kukat https://www.leica-microsystems.com/10866 CLEM Fluorescence Microscopy EM Sample Preparation A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms Electron microscopy (EM) achieves the highest spatial resolution in protein localization, but specific protein EM labeling has lacked generally applicable genetically encoded tags for in situ visualization in cells and tissues. Here we introduce ‘"miniSOG"’ (for mini Singlet Oxygen Generator), a fluorescent flavoprotein engineered from Arabidopsis phototropin 2. https://www.leica-microsystems.com//science-lab/a-genetically-encoded-tag-for-correlated-light-and-electron-microscopy-of-intact-cells-tissues-and-organisms/ Sun, 04 Sep 2011 19:37:00 +0000 https://www.leica-microsystems.com/3833 Laser Microdissection Neuroscience The Mitochondrial Hypothesis of Ageing Why do we grow old? Research scientists have been looking for an answer to this question for many years – particularly against the background of the increase in neurodegenerative diseases among older people such as Morbus Parkinson. https://www.leica-microsystems.com//science-lab/the-mitochondrial-hypothesis-of-ageing/ Mon, 07 Sep 2009 16:11:00 +0000 Dr. Andreas Bender, Dipl. oec.-troph. Anja Schué