Leica Science Lab - Tag : Osteoclast https://www.leica-microsystems.com//science-lab/tag/tags/osteoclast/show/Tag/ Article tagged with Osteoclast en-US https://www.leica-microsystems.com/19922 Fluorescence Microscopy Widefield Microscopy Acute Transcriptional Up-regulation Specific to Osteoblasts/Osteoclasts in Medaka Fish Immediately after Exposure to Microgravity Bone loss is a serious problem in spaceflight; however, the initial action of microgravity has not been identified. To examine this action, we performed live-imaging of animals during a space mission followed by transcriptome analysis using medaka transgenic lines expressing osteoblast and osteoclastspecific promoter-driven GFP and DsRed. In live-imaging for osteoblasts, the intensity of osterix- or osteocalcin-DsRed fluorescence in pharyngeal bones was significantly enhanced 1 day after launch; and this enhancement continued for 8 or 5 days. https://www.leica-microsystems.com//science-lab/acute-transcriptional-up-regulation-specific-to-osteoblastsosteoclasts-in-medaka-fish-immediately-after-exposure-to-microgravity/ Tue, 13 Feb 2018 23:00:00 +0000