Leica Science Lab - Tag : Parkinson https://www.leica-microsystems.com//science-lab/tag/tags/parkinson/show/Tag/ Article tagged with Parkinson en-US https://www.leica-microsystems.com/19973 Widefield Microscopy Effect of curcumin analogs onα-synuclein aggregation and cytotoxicity Alpha-synuclein (α-Syn) aggregation into oligomers and fibrils is associated with dopaminergic neuron loss occurring in Parkinson’s disease (PD) pathogenesis. Compounds that modulate α-Syn aggregation and interact with preformed fibrils/oligomers and convert them to less toxic species could have promising applications in the drug development efforts against PD. Curcumin is one of the Asian food ingredient which showed promising role as therapeutic agent against many neurological disorders including PD. https://www.leica-microsystems.com//science-lab/effect-of-curcumin-analogs-ona-synuclein-aggregation-and-cytotoxicity/ Sun, 04 Mar 2018 23:00:00 +0000 https://www.leica-microsystems.com/2469 Laser Microdissection Neuroscience The Morbus Parkinson Puzzle A characteristic sign of M. Parkinson is the deterioration of dopaminergic neurons in the mid-brain, specifically in the substantia nigra (SN, black substance). Different causes and forms of this disease have been identified. In the case of the genetic familial form, for example, it has been possible to identify various genes that have a causal influence for M. Parkinson. https://www.leica-microsystems.com//science-lab/the-morbus-parkinson-puzzle/ Thu, 27 Mar 2014 11:11:00 +0000 Dr. Falk Schlaudraff, Dr. Olaf Spörkel https://www.leica-microsystems.com/6773 Laser Microdissection K-ATP Channels in Dopamine Substantia Nigra Neurons Control Bursting and Novelty-induced Exploration Phasic activation of the dopamine (DA) midbrain system in response to unexpected reward or novelty is critical for adaptive behavioral strategies. This activation of DA midbrain neurons occurs via a synaptically triggered switch from low-frequency background spiking to transient high-frequency burst firing. We found that, in medial DA neurons of the substantia nigra (SN), activity of ATP-sensitive potassium (K-ATP) channels enabled NMDA-mediated bursting in vitro as well as spontaneous in vivo burst firing in anesthetized mice. https://www.leica-microsystems.com//science-lab/k-atp-channels-in-dopamine-substantia-nigra-neurons-control-bursting-and-novelty-induced-exploration/ Thu, 04 Oct 2012 22:00:00 +0000 Julia Schiemann, Dr. Falk Schlaudraff, Dr. Verena Klose, Markus Bingmer, Prof. Susumu Seino, Dr. Peter J. Magill, Ph.D. Kareem A. Zaghloul, Dr. Gaby Schneider, Prof. Birgit Liss, Prof. Jochen Röper https://www.leica-microsystems.com/3833 Laser Microdissection Neuroscience The Mitochondrial Hypothesis of Ageing Why do we grow old? Research scientists have been looking for an answer to this question for many years – particularly against the background of the increase in neurodegenerative diseases among older people such as Morbus Parkinson. https://www.leica-microsystems.com//science-lab/the-mitochondrial-hypothesis-of-ageing/ Mon, 07 Sep 2009 16:11:00 +0000 Dr. Andreas Bender, Dipl. oec.-troph. Anja Schué