Live-Cell Imaging Techniques
The understanding of complex and/or fast cellular dynamics is an important step for exploring biological processes. Therefore, today’s life science research is increasingly focused on dynamic…Read article
Imaging of Anti-Cancer Drug Uptake in Spheroids using DLS
Spheroid 3D cell culture models mimic the physiology and functions of living tissues making them a useful tool to study tumor morphology and screen anti-cancer drugs. The drug AZD2014 is a recognized…Read article
STELLARIS Contributes to Understanding COVID-19 Infection
What are the structural and functional consequences of a SARS-CoV-2 infection? To answer this important question, the authors used 3D cultures that mimic an airway epithelium and used different…Read article
Artificial Intelligence and Confocal Microscopy – What You Need to Know
This list of frequently asked questions provides “hands-on” answers and is a supplement to the introductory article about AiviaMotion "How Artificial Intelligence Enhances Confocal Imaging"Read articleHow Artificial Intelligence Enhances Confocal Imaging
In this article, we show how artificial intelligence (AI) can enhance your imaging experiments. Namely, how AiviaMotion improves image quality while capturing the temporal dynamics of your live-cell…Read article
Benefits of Combining STED and Lifetime
In this interview, Professor Alberto Diaspro talks about the advantages of the White Light Laser and the TauSTED capabilities of STELLARIS 8 STED. He speaks about his experience with the confocal…Read article
Spectroscopic Evaluation of Red Blood Cells
Hemoglobinopathies are a major healthcare problem. This study presents a possible diagnostic tool for thalassemia which is based on confocal spectroscopy. This approach exploits spectral detection and…Read article
Download TauSTED Infographic
TauSTED combines the optical signals from STED and the physical information from fluorescence lifetime at confocal speeds. Outstanding STED resolution and image quality is achieved due to background…Read article
Visualization of Submitochondrial Protein Distributions
By allowing visualization of submitochondrial protein distributions, fluorescence nanoscopy offers significant advantages for understanding cell death control. How cells manage, and control…Read article
The Cryo-CLEM Journey
This article describes the Cryo-CLEM technology and the benefits it can provide for scientists. Additionally, some scientific publications are highlighted. Recent developments in cryo electron…Read article
DNA Replication in Cancer Cells
DNA synthesis can be impeded by collisions between the DNA replication machinery and co-transcriptional R-loops leading to a major source of genomic instability in cancer cells. In this paper we…Read article
Fluorescence Lifetime-based Imaging Gallery
Confocal microscopy relies on the effective excitation of fluorescence probes and the efficient collection of photons emitted from the fluorescence process. One aspect of fluorescence is the emission…Read article
Visualizing Protein Degradation and Aggregation in the Living Cell
Our guest speaker, Prof Dr Eric Reits, presents his work on neurodegenerative disorders. Reits’ group are experts on the subject of Huntington’s disease and work towards identifying leads for…Read article
Life Beyond the Pixels: Deep Learning Methods for Single Cell Analysis
Our guest speaker Prof Dr Peter Horvath presents his work on single cell-based large-scale microscopy experiments. This novel targeting approach includes the use of machine learning models and…Read article
Phasor FLIM Detects Metabolic Differences
The maintenance of normal blood glucose levels is defective in diabetes caused by dysfunction of the alpha and beta cells in islets. To understand these regularities, we used multiphoton phasor-FLIM…Read article
Tissue Image Gallery
Visual analysis of animal and human tissues is critical to understand complex diseases such as cancer or neurodegeneration. From basic immunohistochemistry to intravital imaging, confocal microscopy…Read articleSuper-Resolution Microscopy Image Gallery
Due to the diffraction limit of light, traditional confocal microscopy cannot resolve structures below ~240 nm. Super-resolution microscopy techniques, such as STED, PALM or STORM or some…Read article
Live Cell Imaging Gallery
Live cell microscopy techniques are fundamental to get a better understanding of cellular and molecular function. Today, widefield microscopy is the most common technique used to visualize cell…Read article
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